.I 1
.U
87049087
.S
Am J Emerg Med 8703; 4(6):491-5
.M
Allied Health Personnel/*; Electric Countershock/*; Emergencies; Emergency Medical Technicians/*; Human; Prognosis; Recurrence; Support, U.S. Gov't, P.H.S.; Time Factors; Transportation of Patients; Ventricular Fibrillation/*TH.
.T
Refibrillation managed by EMT-Ds: incidence and outcome without paramedic back-up.
.P
JOURNAL ARTICLE.
.W
Some patients converted from ventricular fibrillation to organized rhythms by defibrillation-trained ambulance technicians (EMT-Ds) will refibrillate before hospital arrival. The authors analyzed 271 cases of ventricular fibrillation managed by EMT-Ds working without paramedic back-up. Of 111 patients initially converted to organized rhythms, 19 (17%) refibrillated, 11 (58%) of whom were reconverted to perfusing rhythms, including nine of 11 (82%) who had spontaneous pulses prior to refibrillation. Among patients initially converted to organized rhythms, hospital admission rates were lower for patients who refibrillated than for patients who did not (53% versus 76%, P = NS), although discharge rates were virtually identical (37% and 35%, respectively). Scene-to-hospital transport times were not predictively associated with either the frequency of refibrillation or patient outcome. Defibrillation-trained EMTs can effectively manage refibrillation with additional shocks and are not at a significant disadvantage when paramedic back-up is not available.
.A
Stults KR; Brown DD.
.I 2
.U
87049088
.S
Am J Emerg Med 8703; 4(6):496-500
.M
Antidepressive Agents, Tricyclic/*PO; Arrhythmia/PP; California; Electrocardiography; Emergencies; Emergency Service, Hospital/*; Female; Human; Length of Stay; Male; Prognosis; Retrospective Studies; Tachycardia, Sinus/DI/TH.
.T
Tricyclic antidepressant overdose: emergency department findings as predictors of clinical course.
.P
JOURNAL ARTICLE.
.W
There is controversy regarding the appropriate utilization of health care resources in the management of tricyclic antidepressant overdosage. Antidepressant overdose patients presenting to the emergency department (ED) are routinely admitted to intensive care units, but only a small proportion develop cardiac arrhythmias or other complications requiring such an environment. The authors reviewed the findings in 165 patients presenting to an ED with antidepressant overdose. They found that major manifestations of toxicity on ED evaluation (altered mental status, seizures, arrhythmias, and conduction defects) were commonly associated with a complicated hospital course. Patients with the isolated findings of sinus tachycardia or QTc prolongation had no complications. No patient experienced a serious toxic event without major evidence of toxicity on ED evaluation and continued evidence of toxicity during the hospital course. These data support the concept that proper ED evaluation can identify a large body of patients with trivial ingestions who may not require hospital observation.
.A
Foulke GE; Albertson TE; Walby WF.
.I 3
.U
87049089
.S
Am J Emerg Med 8703; 4(6):501-3
.M
Adult; Aircraft/*; Altitude/*; Blood Gas Monitoring, Transcutaneous/*MT; Conjunctiva/*ME; Female; Human; Male; Monitoring, Physiologic/*MT; Regression Analysis; Transportation of Patients/*MT.
.T
Transconjunctival oxygen monitoring as a predictor of hypoxemia during helicopter transport.
.P
JOURNAL ARTICLE.
.W
As the use of helicopters for air transport of critically ill patients increases, the availability of monitoring devices for physiological parameters during flight becomes important. It has long been known that arterial PO2 (PaO2) decreases during unsupplemented, non-pressurized flight. In this study, the authors examined the use of the transconjunctival oxygen (cjO2) monitor for assessing the adequacy of arterial oxygenation during helicopter flight in four healthy volunteers. Arterial PaO2 as measured by conventional blood gas analysis was compared with cjO2 at ground level, 5,000 feet, and 10,000 feet altitude. Mean PaO2 dropped significantly from 93.5 to 81.5 to 58.5 mm Hg, respectively (P less than 0.001, analysis of variance with repeated measures). Mean cjO2 also decreased significantly from 63.8 to 52.0 to 34.8 mm Hg, respectively (P less than 0.001, analysis of variance with repeated measures). Within individual subjects, cjO2 was an accurate predictor of PaO2 (P less than 0.001, multiple regression analysis). The relationship between cjO2 and PaO2 was linear with a regression coefficient of 1.147. The authors conclude that the transconjunctival O2 monitor may be useful for monitoring the adequacy of arterial oxygenation during helicopter flight in hemodynamically stable patients. The results of study also support the use of supplemental oxygen in all patients subjected to helicopter transport.
.A
Shufflebarger C; Jehle D; Cottington E; Martin M.
.I 4
.U
87049090
.S
Am J Emerg Med 8703; 4(6):504-6
.M
Adolescence; Adult; Aged; Blood Glucose/*ME; Diabetes Mellitus/BL; Emergencies; Female; Glucose/*AD; Human; Hypoglycemia/*TH; Male; Middle Age; Prospective Studies; Solutions.
.T
Serum glucose changes after administration of 50% dextrose solution: pre- and in-hospital calculations.
.P
JOURNAL ARTICLE.
.W
A prospective clinical trial was conducted to estimate the rise in serum glucose level after an intravenous bolus of 50 ml of 50% dextrose solution (D-50) in the emergency department setting. Fifty one subjects with altered levels of consciousness were studied. Of these, 23 patients were known diabetics, and 28 were not diabetic. The change in glucose level for the total study group ranged from a low of 37 mg/dl to a high of 370 mg/dl, with a mean of 166 +/- 77 mg/dl. The mean for the diabetic and non-diabetic groups were 177 +/- 80 mg/dl and 154 +/- 75 mg/dl. These results suggest that serum glucose levels cannot be quantitatively predicted after a single intravenous bolus of D-50.
.A
Adler PM.
.I 5
.U
87049092
.S
Am J Emerg Med 8703; 4(6):511-3
.M
Aged; Aged, 80 and over; Case Report; Female; Human; Intubation, Gastrointestinal/*AE; Pneumothorax/*ET/RA/TH; Suicide, Attempted.
.T
Nasogastric intubation: morbidity in an asymptomatic patient.
.P
JOURNAL ARTICLE.
.W
An unusual case of a misdirected nasogastric tube is described. An elderly woman was brought to an emergency department following intentional drug overdose. Initially unrecognized errant placement of a large-bore nasogastric tube resulted in tension pneumothorax, pneumonia, and subsequent death. Pertinent medical literature is reviewed, clinical considerations for the elderly patient are discussed, and suggestions for proper nasogastric tube placement are offered.
.A
Gough D; Rust D.
.I 6
.U
87049093
.S
Am J Emerg Med 8703; 4(6):514-5
.M
Abdominal Injuries/ET; Accidents, Occupational; Accidents, Traffic/*; Adult; Amputation; Blood Transfusion/*; Case Report; Female; Fractures/ET; Human; Pelvic Bones/IN; Shock, Hemorrhagic/ET/*TH; Wounds, Nonpenetrating/*CO.
.T
Massive transfusion without major complications after trauma.
.P
JOURNAL ARTICLE.
.W
A case of massive degloving injury of the trunk, with open pelvic fracture, and evisceration of abdominal contents from blunt trauma is presented. The most significant aspect of this case was the transfusion of 173 units of packed cells and 176 units of fresh frozen plasma in the first thirty hours. The patient ultimately recovered and returned to work.
.A
Brotman S; Lamonica C; Cowley RA.
.I 7
.U
87049094
.S
Am J Emerg Med 8703; 4(6):516-9
.M
Adult; Carbon Monoxide Poisoning/CO/*TH; Female; Human; Labor; Pregnancy; Pregnancy Complications/*TH; Pregnancy Trimester, Third; Respiration, Artificial; Respiratory Distress Syndrome, Adult/ET/*TH.
.T
Acute carbon monoxide poisoning during pregnancy.
.P
JOURNAL ARTICLE.
.W
The course of a pregnant patient at term who was acutely exposed to carbon monoxide is described. A review of the fetal-maternal carboxyhemoglobin relationships and the differences in fetal oxyhemoglobin physiology are used to explain the recommendation that pregnant women with carbon monoxide poisoning should receive 100% oxygen therapy for up to five times longer than is otherwise necessary. The role of hyperbaric oxygen therapy is considered.
.A
Margulies JL.
.I 8
.U
87049096
.S
Am J Emerg Med 8703; 4(6):523-4
.M
Case Report; Child, Preschool; Drug Administration Routes; Emergencies; Human; Male; Phenytoin/*AD/BL; Status Epilepticus/BL/*DT; Tibia.
.T
Intraosseous infusion of phenytoin.
.P
JOURNAL ARTICLE.
.W
In the critically ill child, administration of fluids and medications via the intraosseous route often proves life-saving. The authors describe the case of a child with status epilepticus in whom phenytoin was administered via the intraosseous route, and seizure resolution and therapeutic serum levels were achieved. Intraosseous drug administration should be reserved for the rare critically ill child in whom vascular access proves impossible.
.A
Walsh-Kelly CM; Berens RJ; Glaeser PW; Losek JD.
.I 9
.U
87049098
.S
Am J Emerg Med 8703; 4(6):532-6
.M
Alcohol Drinking; Case Report; Emergencies; Esophageal Diseases/CO/*DI/SU; Human; Male; Middle Age; Rupture, Spontaneous; Syndrome; Vomiting/ET.
.T
Boerhaave's syndrome: an elusive diagnosis.
.P
JOURNAL ARTICLE.
.W
Boerhaave's syndrome represents a diagnostic dilemma for the emergency physician. The prognosis of this truly life-threatening emergency is darkened by any significant diagnostic delay. Unfortunately, classic or expected symptoms and signs are frequently absent at presentation, a circumstance that leads to frequent misdiagnosis. Two cases of Boerhaave's syndrome with "atypical" clinical presentations are reviewed and discussed. It is clear that Boerhaave's syndrome should always be suspected in the evaluation of any sudden chest, abdominal, or back pain associated with emesis. However, emphasis should be placed on the fact that this entity may occur without emesis. The chest radiograph is the most helpful diagnostic aid. Undoubtedly, maintenance of a high degree of suspicion by the emergency physician for Boerhaave's syndrome will lead consistently to earlier diagnosis, and subsequent aggressive intervention should result in considerable reduction in rates of both morbidity and mortality.
.A
Schwartz JA; Turnbull TL; Dymowski J; Uehara DT.
.I 10
.U
87049099
.S
Am J Emerg Med 8703; 4(6):537-9
.M
Adult; Case Report; Electrocardiography/*; Extrasystole/*PP; Female; Human; Male; Middle Age; Tachycardia, Sinus/*PP; Tachycardia, Supraventricular/*PP.
.T
Cases in electrocardiography.
.P
JOURNAL ARTICLE.
.A
Zimmers T.
.I 11
.U
87049100
.S
Am J Emerg Med 8703; 4(6):540-2
.M
Bone Marrow; Child; Child, Preschool; Drug Administration Routes/IS/*MT; Human; Infant; Needles.
.T
Intraosseous infusions: a usable technique.
.P
JOURNAL ARTICLE.
.W
Intraosseous infusions were widely used in pediatric patients during the 1930s and 1940s. Recent reports have re-introduced this concept and confirmed its safety and ready accessability for fluid and drug administration. However, these reports have not addressed the difficulties encountered during insertion of the intraosseous needle. Spinal needles, standard metal intravenous (IV) needles, and bone marrow biopsy needles have been suggested for intraosseous infusion. These needles were tested for ease of insertion on a pediatric cadaver leg. The site for needle placement was also evaluated during the study. It was found that the 13-gauge Kormed/Jamshidi disposable bone marrow/aspiration needle was the easiest to insert and did not plug with bone or tissue during insertion. An area proximal to the medial malleolus was found to provide a stable, relatively flat, and easily penetrable location for needle placement. This method was successfully utilized in ten pediatric and five adult patients. Intraosseous needle placement is a safe, rapid method to gain access to the venous circulation. By utilizing these techniques, a stable, usable fluid line can be established in even the most dehydrated pediatric patients.
.A
Iserson KV; Criss E.
.I 12
.U
87049101
.S
Am J Emerg Med 8703; 4(6):543-4
.M
Adult; Case Report; Cellulitis/CI; Human; Injections, Intravenous; Male; Pulmonary Edema/CI; Suicide, Attempted/*; Turpentine/*AD.
.T
Intravenous hydrocarbon abuse.
.P
JOURNAL ARTICLE.
.W
The case of a man who injected turpentine intravenously in an attempt to kill himself is reported. The patient developed immediate pulmonary edema and hypoxia, followed later by cellulitis at the site of injection. Although only one death to date has been attributed to this form of chemical abuse, extensive local reactions, pulmonary involvement, central nervous system depression, and febrile reactions should be anticipated, and such patients should be admitted to the hospital. Patients should be observed for local reactions and myonecrosis around the site of injection, especially as these occur 12-24 hours later.
.A
Wason S; Greiner PT.
.I 13
.U
87049102
.S
Am J Emerg Med 8703; 4(6):545-8
.M
Abdomen; Administration, Inhalation; Adolescence; Adult; Alopecia/CI; Case Report; Cocaine/*; Drug Contamination; Human; Hypertension/CI; Male; Pain/CI; Substance Abuse/*; Thallium/*PO.
.T
Thallium poisoning in cocaine abusers.
.P
JOURNAL ARTICLE.
.W
The users of illicit drugs is endangered by both unpredictable concentrations of the drugs and by unexpected adulterants that may be present. Cocaine has been adulterated or admixed with numerous substances, among them local anesthetics, amphetamine, phencyclidine, and strychnine. We report three cases of thallium poisoning following nasal insufflation of a substance that was believed to have been cocaine.
.A
Insley BM; Grufferman S; Ayliffe HE.
.I 14
.U
87049103
.S
Am J Emerg Med 8703; 4(6):549-51
.M
Adult; Case Report; Ethchlorvynol/*; Female; Human; Injections, Intravenous; Male; Pulmonary Edema/*CI; Substance Abuse/*.
.T
Pulmonary edema induced by intravenous ethchlorvynol.
.P
JOURNAL ARTICLE.
.W
The intravenous injection of ethchlorvynol is an uncommon cause of noncardiac pulmonary edema. Two cases of intravenous ethchlorvynol-induced pulmonary edema are presented. The patients fell asleep after injecting the liquid contents of Placydil capsules (ethchlorvynol) and awoke several hours later with severe dyspnea. Arterial blood gases demonstrated marked hypoxia. Chest radiographs revealed bilateral diffuse alveolar densities. The patients' symptoms and radiographic findings resolved after several days of supportive care. Changes in the lung caused by ethchlorvynol may be the result of direct effect of the drug on the lung.
.A
Conces DJ Jr; Kreipke DL; Tarver RD.
.I 15
.U
87049104
.S
Am J Emerg Med 8703; 4(6):552-3
.M
Adolescence; Atropine/*TU; Baclofen/*PO; Bradycardia/CI/*DT; Case Report; Human; Hypotension/CI/*DT; Male.
.T
Atropine in the treatment of baclofen overdose.
.P
JOURNAL ARTICLE.
.W
A patient suffering baclofen overdose successfully treated with atropine is reported. Three hours after admission for ingestion of at least 300 mg baclofen as a single dose, the patient became comatose and subsequently bradycardic, hypotensive, and hypothermic. A prompt increase in heart rate and blood pressure followed administration of 1 mg of atropine sulfate. Atropine appears to be useful in treating cases of baclofen overdose complicated by bradycardia and hypotension.
.A
Cohen MB; Gailey RA; McCoy GC.
.I 16
.U
87049105
.S
Am J Emerg Med 8703; 4(6):554-5
.M
Administration, Oral; Adolescence; Burns, Chemical/*ET; Case Report; Colloids; Epiglottis/*IN; Human; Male; Pharynx/*IN; Salicylic Acids/*AD; Suicide, Attempted/*; Tongue/*IN.
.T
Ingestion of Compound W, an unusual caustic.
.P
JOURNAL ARTICLE.
.W
A case of an unusual caustic ingestion involving Compound W, an over the counter wart remover is presented. Chemical burns of the tongue, pharynx and larynx developed. The active ingredient in this preparation: salicylic acid in a flexible collodion vehicle produces caustic injury through a keratolytic action, which may be enhanced by the presence of collodion.
.A
Sacchetti A; Ramoska E.
.I 17
.U
87049106
.S
Am J Emerg Med 8703; 4(6):570-1
.M
Allied Health Personnel/*; Electric Countershock/*; Emergency Medical Technicians/*; Human; Lidocaine/TU; Recurrence; Ventricular Fibrillation/MO/*TH.
.T
EMT-D fibrillation: more shocks for the future [editorial]
.P
EDITORIAL.
.A
Thompson BM.
.I 18
.U
87049107
.S
Am J Emerg Med 8703; 4(6):572-4
.M
Adolescence; Child; Child, Preschool; Emergencies/*; Female; G Suits/*UT; Human; Male; Massachusetts; Retrospective Studies; Transportation of Patients.
.T
Estimating prehospital demand for pediatric antishock garments.
.P
JOURNAL ARTICLE.
.A
McCabe CJ; Cadigan RT; Bugarin CE; Azzara CV.
.I 19
.U
87049108
.S
Am J Emerg Med 8703; 4(6):574-5
.M
Emergency Service, Hospital/*; Human; Thoracic Injuries/*SU; Transportation of Patients/*MT; Wounds, Penetrating/*MO.
.T
Emergency department thoracotomy [letter]
.P
LETTER.
.A
Hoffman JR.
.I 20
.U
87049109
.S
Am J Emerg Med 8703; 4(6):575-7
.M
Adult; Career Choice/*; Emergency Medicine/*ED; Female; Goals; Human; Internship and Residency/*; Male.
.T
Academic aspirations of residents.
.P
JOURNAL ARTICLE.
.A
Lundberg T; Hedges JR.
.I 21
.U
87049271
.S
ASAIO Trans 8703; 32(1):104-7
.M
Adult; Antithrombin III/BL; Blood Proteins/AN; Case Report; Female; Fibrinogen/AN; Heparin/*TU; Human; Hypercholesterolemia/BL/*TH; Lipoproteins, HDL Cholesterol/BL; Lipoproteins, LDL/*BL/IP; Lipoproteins, LDL Cholesterol/BL; Male; Middle Age; Plasma Volume; Plasminogen/AN; Precipitation.
.T
Selective continuous elimination of low density lipoproteins (LDL) by heparin precipitation: first clinical application.
.P
JOURNAL ARTICLE.
.A
Eisenhauer T; Armstrong VW; Wieland H; Fuchs C; Nebendahl K; Scheler F; Seidel D.
.I 22
.U
87049272
.S
ASAIO Trans 8703; 32(1):108-10
.M
Anaphylaxis; Cellulose/*AA/AN; Ethylene Oxide/AE/*AN; Hemodialysis/AE; Human; Kinetics; Membranes, Artificial/*; Sterilization.
.T
Extractable ethylene oxide from cuprammonium cellulose plate dialyzers: importance of potting compound.
.P
JOURNAL ARTICLE.
.W
Our results suggest that ethylene oxide retention after sterilization is increased in cuprammonium cellulose plate dialyzers containing potting compound. In contrast, cuprammonium cellulose plate dialyzers without potting compound were characterized by a rapid disappearance of retained ethylene oxide after sterilization. Whether these findings explain the low incidence of SARD with cuprammonium cellulose plate dialyzers that do not contain potting material is a matter for continued study and experimentation.
.A
Ing TS; Daugirdas JT.
.I 23
.U
87049273
.S
ASAIO Trans 8703; 32(1):11-6
.M
Adult; Aged; Case Report; Comparative Study; Creatinine/ME; Female; Human; Kidney Failure, Chronic/*TH; Male; Middle Age; Peritoneal Dialysis/*; Peritoneal Dialysis, Continuous Ambulatory/*; Ultrafiltration; Urea/ME.
.T
Peritoneal dialysis.
.P
JOURNAL ARTICLE.
.A
Nolph KD; Twardowski ZJ; Khanna R.
.I 24
.U
87049275
.S
ASAIO Trans 8703; 32(1):114-9
.M
Animal; Carotid Arteries/*TR/UL; Collagen/*AN; Compliance; Delayed-Action Preparations; Dogs; Heparin/AD/AN/*TU; Microscopy, Electron, Scanning.
.T
Development of a small caliber vascular graft by a new crosslinking method incorporating slow heparin release collagen and natural tissue compliance.
.P
JOURNAL ARTICLE.
.A
Noishiki Y; Miyata T; Kodaira K.
.I 25
.U
87049276
.S
ASAIO Trans 8703; 32(1):120-2
.M
Adolescence; Adult; Aged; Aluminum/*TU; Antacids/AN/*TU; Hemodialysis/*; Human; Middle Age; Strontium/AN/*BL; Uremia/*BL/TH.
.T
Strontium overload in uremic patients on regular dialytic treatment.
.P
JOURNAL ARTICLE.
.A
Canavese C; Pacitti A; Salomone M; Santoro MA; Stratta P; Mangiarotti G; Talarico S; Sabbioni E; Pietra R; Vercellone A.
.I 26
.U
87049277
.S
ASAIO Trans 8703; 32(1):123-6
.M
Cellulose/AA; Human; Kidney Failure, Acute/TH; Kidney Failure, Chronic/TH; Kidney, Artificial/*; Membranes, Artificial; Prosthesis Design; Uremia/TH.
.T
A bag-filter model of a new pret a porter artificial kidney.
.P
JOURNAL ARTICLE.
.A
Bazzato G; Coli U; Landini S; Fracasso A; Morachiello P; Righetto F; Scanferla F.
.I 27
.U
87049278
.S
ASAIO Trans 8703; 32(1):127-9
.M
Calcium/BL; Calcium Carbonate/*TU; Female; Hemodialysis/*MT; Human; Kidney Failure, Chronic/BL/*TH; Male; Phosphates/*ME; Phosphorus/BL.
.T
Calcium carbonate as a phosphate binder in hemodialysis patients.
.P
JOURNAL ARTICLE.
.W
Calcium carbonate appears to be as effective as aluminum hydroxide in binding dietary phosphorus in hemodialysis patients. The long-term safety of this medication appears acceptable in view of today's therapeutic options.
.A
Taber TE; Hegemen TF; York S.
.I 28
.U
87049279
.S
ASAIO Trans 8703; 32(1):130-3
.M
Animal; Artificial Organs; Capsules; Endocrine Glands/*TR; Peritoneal Cavity/*SU; Rats; Rats, Inbred Strains.
.T
An intraperitoneal receptacle for macroencapsulated endocrine tissue.
.P
JOURNAL ARTICLE.
.A
Aebischer P; Panol G; Galletti PM.
.I 29
.U
87049280
.S
ASAIO Trans 8703; 32(1):134-7
.M
Animal; Artificial Organs/*; Hypocalcemia/*TH; Microscopy, Electron; Parathyroid Glands/CY/*TR/UL; Peritoneal Cavity; Rats; Rats, Inbred Strains.
.T
A bioartificial parathyroid.
.P
JOURNAL ARTICLE.
.A
Aebischer P; Russell PC; Christenson L; Panol G; Monchik JM; Galletti PM.
.I 30
.U
87049281
.S
ASAIO Trans 8703; 32(1):138-42
.M
Adult; Bilirubin/BL; Female; Fluorescence; Human; Hyperbilirubinemia/ET/*TH; Liver Diseases/*TH; Male; Middle Age; Phototherapy/*; Plasma/*/RE.
.T
Innovation in blood purification for hepatic failure: direct photoirradiation of plasma.
.P
JOURNAL ARTICLE.
.A
Totsune K.
.I 31
.U
87049282
.S
ASAIO Trans 8703; 32(1):143-4
.M
Human; Membranes, Artificial/*; Middle Ear Ventilation/*/IS; Oxygen; Permeability.
.T
Permeation rate to oxygen of membrane tympanostomy tubes.
.P
JOURNAL ARTICLE.
.A
Rodgers VG; Borovetz HS.
.I 32
.U
87049284
.S
ASAIO Trans 8703; 32(1):148-50
.M
Animal; Blood Glucose/*AN; Dogs; Electrodes; Insulin Infusion Systems/*; Prosthesis Design; Rabbits; Support, U.S. Gov't, P.H.S..
.T
Short-term in vivo operation of a glucose sensor.
.P
JOURNAL ARTICLE.
.A
Gough DA; Armour JC; Lucisano JY; McKean BD.
.I 33
.U
87049285
.S
ASAIO Trans 8703; 32(1):151-6
.M
Adhesiveness; Animal; Dogs; Elasticity; Human; Rubber/*; Stress, Mechanical; Surgery; Tissue Adhesives/*.
.T
A novel elastomeric surgical adhesive: design, properties, and in vivo performances.
.P
JOURNAL ARTICLE.
.A
Matsuda T; Itoh T; Yamaguchi T; Iwata H; Hayashi K; Uemura S; Ando T; Adachi S; Nakajima N.
.I 34
.U
87049286
.S
ASAIO Trans 8703; 32(1):157-62
.M
Acrylic Resins/*; Electrochemistry; Implants, Artificial/*; Kinetics; Muscle Contraction; Muscles/PH; Povidone/*.
.T
Contractile behavior of electrically activated mechanochemical polymer actuators.
.P
JOURNAL ARTICLE.
.A
De Rossi DE; Chiarelli P; Buzzigoli G; Domenici C; Lazzeri L.
.I 35
.U
87049287
.S
ASAIO Trans 8703; 32(1):163-7
.M
Animal; Aorta/PA; Blood Pressure; Cholesterol/BL; Heart Rate; Hypercholesterolemia/PA/PP/*TH; Male; Plasmapheresis/*; Rabbits; Regional Blood Flow.
.T
Long-term repetitive plasmapheresis in hypercholesterolemic rabbits.
.P
JOURNAL ARTICLE.
.A
Kutsumi Y; Fujiwara R; Tamai T; Takai H; Nakai T; Miyabo S.
.I 36
.U
87049289
.S
ASAIO Trans 8703; 32(1):17-23
.M
Adolescence; Adult; Bicarbonates/*TU; Child; Evaluation Studies; Follow-Up Studies; Hemodialysis/*/AE/MT; Hospitalization; Human; Middle Age; Morbidity; Risk; Time Factors; Uremia/PP/TH.
.T
Rapid high-efficiency bicarbonate hemodialysis.
.P
JOURNAL ARTICLE.
.A
Keshaviah P; Collins A.
.I 37
.U
87049290
.S
ASAIO Trans 8703; 32(1):171-6
.M
Aged; Aluminum/BL/*PO; Case Report; Diabetic Nephropathies/TH; Encephalitis/*CI; Female; Hemodialysis/*AE; Human; Kidney Failure, Chronic/ET/*TH; Male; Middle Age; Nephrotic Syndrome/CO/*TH; Uremia/*TH.
.T
Acute fatal hyperaluminemic encephalopathy in undialyzed and recently dialyzed uremic patients.
.P
JOURNAL ARTICLE.
.A
Bakir AA; Hryhorczuk DO; Berman E; Dunea G.
.I 38
.U
87049292
.S
ASAIO Trans 8703; 32(1):181-3
.M
Animal; Arteries/ME/*SU; Collagen/BI; Dogs; Hydroxyproline/BI; Laser Surgery/*; Support, U.S. Gov't, P.H.S.; Tensile Strength; Veins/ME/*SU.
.T
Laser welding of large diameter arteries and veins.
.P
JOURNAL ARTICLE.
.W
Based on our preliminary studies and the results of this study, we conclude that argon laser welding of 4-8 mm internal diameter veins, arteries, and arteriovenous fistulas may have several potential advantages compared to conventional suture techniques. The benefits of laser repairs may include improved mechanical properties, and absence of the foreign body response related to sutures. Laser welding is sterile, nontactile and possibly time conserving, and the wounds heal rapidly without aneurysms or excess tissue proliferation.
.A
White RA; Kopchok G; Donayre C; Lyons R; White G; Klein SR; Abergel RP; Uitto J.
.I 39
.U
87049293
.S
ASAIO Trans 8703; 32(1):184-6
.M
Aspirin/*PD; Blood Platelets/DE; Cell Division/DE; Cells, Cultured; Dipyridamole/*PD; Endothelium/*CY/DE; Human; Ibuprofen/*PD; Kinetics; Umbilical Veins.
.T
Effect of antiplatelet drugs on human endothelial cell growth in tissue culture.
.P
JOURNAL ARTICLE.
.A
Evans DK; Campbell J; Herring M; Glover J.
.I 40
.U
87049294
.S
ASAIO Trans 8703; 32(1):187-92
.M
Animal; Blood Platelets/*PH; Blood Vessel Prosthesis/*; Dogs; Femoral Artery/*SU; Femoral Vein/DE/*TR; Fibrinogen/*PH; Indium/DU; Iodine Radioisotopes/DU; Polytetrafluoroethylene/*; Radioisotopes/DU; Support, U.S. Gov't, P.H.S.; Thrombosis/*PP; Tropolone/AA/DU; Vitamin E/BL/*PD.
.T
Quantitation of platelet and fibrinogen deposition on PTFE and vein grafts in dogs and the effect of vitamin E on graft thrombosis in the acute phase.
.P
JOURNAL ARTICLE.
.A
Dewanjee MK; Solis E; Mackey ST; Gonzales G; Chesebro JH; Kaye MP.
.I 41
.U
87049295
.S
ASAIO Trans 8703; 32(1):193-7
.M
Animal; Biocompatible Materials/*; Blood Vessel Prosthesis/*; Dogs; Microscopy, Electron, Scanning; Polyurethanes/*; Silicones/*; Siloxanes/*; Surface Properties; Thrombosis/*PC.
.T
Evaluation of a new antithrombogenic polyurethane-polysiloxane complex biomaterial.
.P
JOURNAL ARTICLE.
.A
Ohkubo N; Hirose H; Matsuda H; Nakano S; Shirakura R; Maeda S; Ohtani M; Yoda R; Kawashima Y.
.I 42
.U
87049296
.S
ASAIO Trans 8703; 32(1):198-200
.M
Adult; Aluminum/*AE; Case Report; Deferoxamine/*TU; Fractures/*DT/ET; Hemodialysis/*AE; Human; Humeral Fractures/DT/ET; Humerus/RA; Kidney Failure, Chronic/TH; Male; Osteomalacia/CI/*CO; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Wound Healing/*DE.
.T
Fracture healing with deferoxamine therapy in a patient with aluminum-associated osteomalacia.
.P
JOURNAL ARTICLE.
.A
Phelps KR; Einhorn TA; Vigorita VJ; Lundin AP; Friedman EA.
.I 43
.U
87049297
.S
ASAIO Trans 8703; 32(1):201-6
.M
Animal; Assisted Circulation/*; Dogs; Electrocardiography; Heart-Assist Devices/*; Myocardial Infarction/PP/*TH; Nuclear Magnetic Resonance/DU/IS/MT.
.T
Therapeutic effect of a left ventricular assist device on acute myocardial infarction evaluated by magnetic resonance imaging.
.P
JOURNAL ARTICLE.
.A
Nakatani T; Takano H; Noda H; Fukuda S; Nishimura T; Yamada Y; Kozuka T; Akutsu T.
.I 44
.U
87049298
.S
ASAIO Trans 8703; 32(1):207-10
.M
Animal; Cattle; Cerebrovascular Disorders/ET; Comparative Study; Heart, Artificial/*/AE; Human; Prosthesis Design; Sheep; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S..
.T
Comparison of clinical and animal recipients of a pneumatic artificial heart.
.P
JOURNAL ARTICLE.
.A
Taenaka Y; Olsen DB; Riebman JB; Burns GB; Crump CL.
.I 45
.U
87049299
.S
ASAIO Trans 8703; 32(1):211-6
.M
Angioplasty, Transluminal/AE/*IS/MT; Animal; Dogs; Heart Failure, Congestive/ET/PP/*TH; Heart-Assist Devices; Hemodynamics.
.T
Experimental evaluation of extrapulmonary arterial balloon pumping (EPABP) for right heart failure of diverse etiologies.
.P
JOURNAL ARTICLE.
.A
Miya J; Maeta H; Asakura T; Hori M.
.I 46
.U
87049300
.S
ASAIO Trans 8703; 32(1):217-20
.M
Animal; Aorta/SU; Assisted Circulation/*; Cardiac Output; Coronary Circulation; Dogs; Heart/PP; Heart Atrium/SU; Heart-Assist Devices/*; Myocardial Infarction/PP/*TH.
.T
The effect of left ventricular assistance on the area of infarcted myocardium.
.P
JOURNAL ARTICLE.
.A
Wei CM; Yada I; Kusagawa M.
.I 47
.U
87049301
.S
ASAIO Trans 8703; 32(1):221-5
.M
Cardiac Output; Emergencies/*; Heart, Artificial/*AE; Human; Hypertension, Pulmonary/ET/TH; Monitoring, Physiologic.
.T
Drive system management of emergency conditions in three permanent total artificial heart patients.
.P
JOURNAL ARTICLE.
.A
Mays JB; Hastings WL; Williams MA; Barker LE; DeVries WC.
.I 48
.U
87049304
.S
ASAIO Trans 8703; 32(1):238-41
.M
Allylamine; Animal; Chronic Disease; Disease Models, Animal; Echocardiography; Heart/DE; Heart Failure, Congestive/CI/PA/*PP; Microscopy, Electron; Myocardium/PA/UL; Sheep; Support, U.S. Gov't, P.H.S..
.T
Large-animal model of chronic congestive heart failure induced by intracoronary allylamine.
.P
JOURNAL ARTICLE.
.A
Beck LS; Strickland RD; Bagley BL; Mortensen JD; Hammond ME; Ashton AH; Head DR; Braun MR; Weiler MJ.
.I 49
.U
87049306
.S
ASAIO Trans 8703; 32(1):242-7
.M
Animal; Assisted Circulation/*; Blood Chemical Analysis; Body Temperature; Cattle; Evaluation Studies; Heart-Assist Devices/*; Human; Implants, Artificial; Prosthesis Design; Respiration; Support, U.S. Gov't, P.H.S..
.T
In vivo evaluation of a permanently implantable thermal ventricular assist system.
.P
JOURNAL ARTICLE.
.W
The System 7 pump/actuator/engine combination has demonstrated biologic compatibility and physiologic effectiveness and responsiveness in five TVAS in vivo studies. The recent 75-day implant supports the feasibility of extended reliability of the system components. Postoperative system maintenance was necessary only because of the nonhermetic design of System 7. However, the ability to pump 11 l/min at 120 beats/min, synchronize at beat rates of 144 beats/min, and pump against mean arterial pressures of more than 150 mmHg while maintaining hematologic and biochemical values within physiologic range sets a very optimistic stage for System 8 hardware. A System 8 concept is shown in Figure 14. The System 8 hardware will include a thermal salt package capable of providing completely untethered circulatory support for a nominal 8-h period. Recharge will be accomplished with a transcutaneous transformer in 1 h. Thermal management problems become minimal, with an average energy input of 15.8 W (peak of 24.9 W). The human preclinical testing of System 8 will start in 1988.
.A
Sugita Y; Navarro RR; White M; Whalen R; Kiraly RJ; Harasaki H; Nose Y.
.I 50
.U
87049307
.S
ASAIO Trans 8703; 32(1):248-52
.M
Animal; Chronic Disease; Disease Models, Animal; Dogs; Heart/*PP; Heart Failure, Congestive/PA/*PP; Heart Ventricle/PP; Myocardium/*PA; Support, U.S. Gov't, P.H.S..
.T
Experimental chronic left ventricular failure in the dog.
.P
JOURNAL ARTICLE.
.A
Hagiwara K; Freed PS; Wasfie T; Bar-Lev A; Mandell G; Cardona R; Stein PD; Sabbah HN; Kantrowitz A.
.I 51
.U
87049309
.S
ASAIO Trans 8703; 32(1):258-62
.M
Comparative Study; Evaluation Studies; Heart/PH/PP; Heart, Artificial/*; Human; Microcomputers; Prosthesis Design; Support, Non-U.S. Gov't; Ultrasonics.
.T
Instrumentation for deriving pneumatic TAH control signals from the driveline pressure and flow.
.P
JOURNAL ARTICLE.
.A
Wurzel D; Wildevuur W; Kolff J.
.I 52
.U
87049310
.S
ASAIO Trans 8703; 32(1):263-8
.M
Animal; Arterioles/PA; Assisted Circulation/*; Cattle; Heart/*PP; Heart Ventricle/PP; Heart-Assist Devices/*; Hemodynamics; Prosthesis Design; Pulse; Regional Blood Flow; Renal Circulation; Support, Non-U.S. Gov't.
.T
Idioperipheral pulsation during nonpulsatile biventricular bypass experiments.
.P
JOURNAL ARTICLE.
.A
Tsutsui T; Sutton C; Harasaki H; Jacobs G; Golding L; Nose Y.
.I 53
.U
87049311
.S
ASAIO Trans 8703; 32(1):269-73
.M
Assisted Circulation/*/AE; Beta-Thromboglobulin/AN; Blood Coagulation; Blood Platelets/PH; Heart-Assist Devices/*/AE; Human; Lactate Dehydrogenase/BL; Prosthesis Design; Stress, Mechanical.
.T
Investigation of the flow in a centrifugal blood pump.
.P
JOURNAL ARTICLE.
.A
Affeld K; Schichl K; Yoganathan A.
.I 54
.U
87049312
.S
ASAIO Trans 8703; 32(1):274-7
.M
Analysis of Variance; Azure Stains; Extracorporeal Circulation/*; Heparin/*BL; Human; Regression Analysis; Stains and Staining.
.T
Rapid assay for heparin during extracorporeal circulation.
.P
JOURNAL ARTICLE.
.A
Ross RL; Whittlesey GC; Splittgerber FH; Salley SO; Klein MD.
.I 55
.U
87049313
.S
ASAIO Trans 8703; 32(1):278-81
.M
Animal; Blood Pressure/*; Heart Surgery/*; Heart Ventricle/SU; Myocardial Contraction/*; Support, U.S. Gov't, P.H.S.; Swine; Systole/*.
.T
Right ventricular end-systolic pressure-dimension relationship during left ventricular bypass in anesthetized pigs.
.P
JOURNAL ARTICLE.
.A
Farrar DJ; Compton PG; Verderber A; Hill JD.
.I 56
.U
87049314
.S
ASAIO Trans 8703; 32(1):282-7
.M
Bioprosthesis/*ST; Heart Valve Prosthesis/*ST; Human; Prosthesis Design; Quality Control; Stress, Mechanical.
.T
Mechanical factors influencing the durability of heart valve pericardial bioprostheses.
.P
JOURNAL ARTICLE.
.A
Gabbay S; Bortolotti U; Josif M.
.I 57
.U
87049317
.S
ASAIO Trans 8703; 32(1):297-9
.M
Animal; Arteriovenous Shunt, Surgical/*/AE; Dogs; Hemodialysis/AE/*MT; Kidney, Artificial/*; Perfusion; Polytetrafluoroethylene/*; Prosthesis Design; Silicones/*; Support, Non-U.S. Gov't; Thrombosis/ET.
.T
PTFE-silicone self-sealing dialysis prosthesis.
.P
JOURNAL ARTICLE.
.A
Schanzer H; Martinelli GP; Bock G; Peirce EC 2d.
.I 58
.U
87049318
.S
ASAIO Trans 8703; 32(1):30-4
.M
Alloys/*; Animal; Anticoagulants/TU; Blood Pressure; Blood Vessel Prosthesis/*; Dogs; Monitoring, Physiologic; Prosthesis Design; Support, Non-U.S. Gov't.
.T
Nonsurgical implantation of a vascular ring prosthesis using thermal shape memory Ti/Ni alloy (Nitinol wire).
.P
JOURNAL ARTICLE.
.A
Sugita Y; Shimomitsu T; Oku T; Murabayashi S; Kambic HE; Harasaki H; Shirey E; Golding L; Nose Y.
.I 59
.U
87049319
.S
ASAIO Trans 8703; 32(1):300-4
.M
Female; Follow-Up Studies; Hematocrit; Hemodialysis/*MT; Human; Kidney, Artificial; Kinetics; Male; Middle Age; Urea/ME.
.T
Long-term experience with routine single-needle dialysis. A review.
.P
JOURNAL ARTICLE.
.A
Vanholder R; Hoenich N; Bogaert AM; Ringoir S.
.I 60
.U
87049320
.S
ASAIO Trans 8703; 32(1):305-8
.M
Anemia/*ET; Female; Hemodialysis/*/AE; Human; Kidney Failure, Chronic/BL/*TH; Male; Manganese/BL; Middle Age; Nickel/BL; Trace Elements/*BL; Zinc/BL.
.T
Trace metals and anemia in chronic hemodialysis patients.
.P
JOURNAL ARTICLE.
.A
Hosokawa S; Nishitani H; Tomoyoshi T; Yoshida O.
.I 61
.U
87049321
.S
ASAIO Trans 8703; 32(1):309-14
.M
Animal; Blood Vessel Prosthesis/*; Comparative Study; Dogs; Endothelium/CY/UL; Evaluation Studies; Female; Male; Microscopy, Electron, Scanning/MT; Polyesters/*.
.T
Evaluation of a new vascular graft prosthesis fabricated from ultrafine polyester fiber.
.P
JOURNAL ARTICLE.
.A
Noishiki Y; Watanabe K; Okamoto M; Kikuchi Y; Mori Y.
.I 62
.U
87049323
.S
ASAIO Trans 8703; 32(1):319-22
.M
Blood Coagulation/*DE; Blood Coagulation Tests; Fibrinolysis/*DE; Human; Kinetics; Microscopy, Electron, Scanning; Polymethacrylic Acids/*PD.
.T
Effect of a hydrogel with long polyethyleneoxide chains on blood coagulation and fibrinolysis.
.P
JOURNAL ARTICLE.
.A
Nakao A; Ohkura K; Nonami T; Harada A; Takagi H; Mori Y.
.I 63
.U
87049324
.S
ASAIO Trans 8703; 32(1):323-6
.M
Adsorption; Blood Coagulation/*DE; Blood Coagulation Factors/*ME; Blood Proteins/*ME; Human; IgG/*; Platelet Adhesiveness/*DE; Polyurethanes/*PD; Serum Albumin/*; Support, U.S. Gov't, P.H.S..
.T
Reduced platelet adhesion and activation of coagulation factors on polyurethane treated with albumin-IgG complex.
.P
JOURNAL ARTICLE.
.A
Mohammad SF; Olsen DB.
.I 64
.U
87049325
.S
ASAIO Trans 8703; 32(1):327-9
.M
Animal; Aorta/*RE/UL; Coronary Vessels/*RE/UL; Dose-Response Relationship, Radiation; Heat; Human; Lasers/*; Microscopy, Electron; Rabbits; Ultraviolet Rays/*.
.T
Thermal effects of far ultraviolet excimer laser radiation on biologic tissue.
.P
JOURNAL ARTICLE.
.A
Wollenek G; Laufer G.
.I 65
.U
87049326
.S
ASAIO Trans 8703; 32(1):330-3
.M
Animal; Cattle; Erythrocytes/UL; Hemoglobins/AN; Hemolysis/*; Mathematics; Membranes, Artificial; Microscopy, Electron, Scanning; Models, Theoretical; Plasmapheresis/*; Pressure.
.T
A model of hemolysis in membrane plasmapheresis.
.P
JOURNAL ARTICLE.
.A
Ding LH; Jaffrin MY; Gupta BB.
.I 66
.U
87049327
.S
ASAIO Trans 8703; 32(1):334-8
.M
Adult; Animal; Blood Vessel Prosthesis/*; Cell Survival; Cells, Cultured; Comparative Study; Cross-Linking Reagents/*; Culture Media; Dogs; Endothelium/*CY; Female; Fibronectins/*; Human; Polyesters; Polytetrafluoroethylene; Pregnancy; Species Specificity; Umbilical Veins; Veins.
.T
Fluid shear disruption of cultured endothelium: the effect of cell species, fibronectin cross-linking and supporting polymer.
.P
JOURNAL ARTICLE.
.A
Lundgren CH; Herring MB; Arnold MP; Glover JL; Bendick PJ.
.I 67
.U
87049329
.S
ASAIO Trans 8703; 32(1):342-5
.M
Animal; Biocompatible Materials/*; Capsules; Chromatography, Gel; Collagen; Drug Screening; Implants, Artificial/*; Lactates/ME; Polymers/ME; Time Factors.
.T
Tissue developed around bioresorbable implants. Load-bearing versus histology.
.P
JOURNAL ARTICLE.
.A
Richardson PD; Sasken H; Parhizgar A; Aebischer P; Panol G; Chiu TH; Galletti PM.
.I 68
.U
87049335
.S
ASAIO Trans 8703; 32(1):363-6
.M
Animal; Biocompatible Materials; Catheters, Indwelling/*; Comparative Study; Diabetes Mellitus, Experimental/*DT; Dogs; Insulin Infusion Systems/*; Polyethylenes/*; Silicone Elastomers/*.
.T
Use of polyethylene-lined silicone rubber cannulae in long-term insulin infusion in the dog.
.P
JOURNAL ARTICLE.
.A
Wigness BD; Rohde TD; Dorman FD; Buchwald H.
.I 69
.U
87049336
.S
ASAIO Trans 8703; 32(1):367-9
.M
Adult; Aluminum/*BL/IP; Case Report; Chromatography, Gel/MT; Deferoxamine/AD/*BL/IP; Female; Hemodialysis/*; Human; Infusions, Intravenous; Male; Middle Age; Molecular Weight; Uremia/*BL/TH.
.T
Chromatographic studies of aluminum-desferrioxamine complex in uremic patients.
.P
JOURNAL ARTICLE.
.A
Canavese C; Pacitti A; Salomone M; Pramotton C; Segoloni G; Bedino S; Testore G; Lamon S; Vercellone A.
.I 70
.U
87049337
.S
ASAIO Trans 8703; 32(1):370-3
.M
Adult; Aged; Aluminum/*TU; Blood/*; Female; Follow-Up Studies; Hematocrit; Hemodialysis/*; Human; Kidney Failure, Chronic/*BL/TH; Male; Middle Age; Phosphates/*BL; Support, Non-U.S. Gov't; Ultrafiltration/*.
.T
Reduction in aluminum load after one year of hemodiafiltration.
.P
JOURNAL ARTICLE.
.A
Ahmad S; Vizzo JE; Scribner BH.
.I 71
.U
87049338
.S
ASAIO Trans 8703; 32(1):374-6
.M
Adult; Aged; Blood Chemical Analysis; Female; Follow-Up Studies; Hemodialysis/*MT; Human; Kidney Failure, Chronic/BL/TH; Male; Middle Age; Support, Non-U.S. Gov't; Time Factors.
.T
Short hemodialysis--10-year follow-up.
.P
JOURNAL ARTICLE.
.A
Raja R; Kramer M; Goldstein S; Caruana R; Lerner A.
.I 72
.U
87049339
.S
ASAIO Trans 8703; 32(1):377-8
.M
Adult; Aged; Hemodialysis/*MT; Human; Kidney Failure, Chronic/*PP/TH; Middle Age; Nutritional Status/*; Parathyroid Hormones/BL; Serum Albumin/AN; Time Factors; Uremia/*PP/TH.
.T
Rapid blood flow short dialysis does not adversely affect clinical, biochemical, or nutritional status of patients.
.P
JOURNAL ARTICLE.
.A
Rubin JE; Friedmann P; Berlyne GM.
.I 73
.U
87049341
.S
ASAIO Trans 8703; 32(1):384-7
.M
Blood/*; Dextrans; Human; Kidney, Artificial/*; Molecular Weight; Structure-Activity Relationship; Support, U.S. Gov't, Non-P.H.S.; Ultrafiltration/*.
.T
Macromolecular charge affects hemofilter solute sieving.
.P
JOURNAL ARTICLE.
.A
Leypoldt JK; Frigon RP; Henderson LW.
.I 74
.U
87049342
.S
ASAIO Trans 8703; 32(1):388-91
.M
Human; Hypercholesterolemia, Familial/BL/*TH; Lipoproteins, LDL/*BL/IP; Microscopy, Electron, Scanning; Plasmapheresis/IS/*MT; Temperature; Ultrafiltration/IS/MT.
.T
Comparison of plasmafractionation filters and filtration techniques in the clinical practice of LDL-apheresis.
.P
JOURNAL ARTICLE.
.A
Kochinke F; Baeyer HV; Schwaner I; Schwerdtfeger R.
.I 75
.U
87049345
.S
ASAIO Trans 8703; 32(1):397-400
.M
Animal; Blood/*; Cattle; Electrolytes/BL; Membranes, Artificial/*; Microscopy, Electron, Scanning; Permeability; Polytetrafluoroethylene/*; Water.
.T
Extraction of solute-free water from blood by membrane distillation.
.P
JOURNAL ARTICLE.
.A
Sakai K; Muroi T; Ozawa K; Takesawa S; Tamura M; Nakane T.
.I 76
.U
87049346
.S
ASAIO Trans 8703; 32(1):401-4
.M
Adult; Aged; Blood/*; Burns/PP/*TH; Catheters, Indwelling; Edema/ET/*TH; Female; Heparin/TU; Human; Kidney Failure, Acute/ET/*TH; Male; Middle Age; Ultrafiltration/*.
.T
Continuous arteriovenous hemofiltration for the treatment of anasarca and acute renal failure in severely burned patients.
.P
JOURNAL ARTICLE.
.A
Hubsher J; Olshan AR; Schwartz AB; Zoranski B; DeClement F; Bendlin A; Hensell D; Brezin JH; Krevolin LE; Chinitz JL.
.I 77
.U
87049347
.S
ASAIO Trans 8703; 32(1):405-9
.M
Blood Component Removal/*IS/MT; Disposable Equipment; Erythrocyte Count; Hematocrit; Human; Leukocyte Count; Membranes, Artificial; Plasma/*; Platelet Count; Polyethylenes.
.T
An automated plasma collector with innovative membrane and cassette-like disposable set.
.P
JOURNAL ARTICLE.
.A
Yamazaki Z; Kanai F; Hiraishi M; Ohnishi K; Idezuki Y; Takahama T; Fujimori Y; Asano K; Inoue N; Shibata Y; et al.
.I 78
.U
87049348
.S
ASAIO Trans 8703; 32(1):410-3
.M
Animal; Blood Component Removal/*IS/MT; Cattle; Ceramics/*; Filtration; Hematocrit; Membranes, Artificial/*; Plasma/*; Support, Non-U.S. Gov't.
.T
Design of a plasma separator using ceramic membranes.
.P
JOURNAL ARTICLE.
.A
Sakurai H; Ozawa K; Takesawa S; Sakai K.
.I 79
.U
87049349
.S
ASAIO Trans 8703; 32(1):414-7
.M
Assisted Circulation/*; Blood/*; Cardiopulmonary Bypass; Creatinine/ME; Female; Heart Surgery; Heart-Assist Devices/*; Human; Intra-Aortic Balloon Pumping/*; Kidney Failure, Acute/ET/*TH; Male; Middle Age; Postoperative Complications/*TH; Ultrafiltration/*.
.T
Continuous renal replacement therapy in patients with acute renal dysfunction undergoing intraaortic balloon pump and/or left ventricular device support.
.P
JOURNAL ARTICLE.
.A
Paganini EP; Suhoza K; Swann S; Golding L; Nakamoto S.
.I 80
.U
87049350
.S
ASAIO Trans 8703; 32(1):418-21
.M
Filtration; Human; Mathematics; Membranes, Artificial; Plasmapheresis/*MT.
.T
Relationship between Staverman's reflection and sieving coefficients in a plasma fractionator.
.P
JOURNAL ARTICLE.
.A
Mineshima M; Hasuo Y; Kaneko I; Era K; Agishi T; Ota K; Sakai K.
.I 81
.U
87049351
.S
ASAIO Trans 8703; 32(1):42-5
.M
Evaluation Studies; Foreign Bodies/*PA; Heart, Artificial/*/AE; Human; Skin/*PA; Support, U.S. Gov't, P.H.S.; Time Factors.
.T
The microscopic evaluation of skin buttons used in a long-term human total artificial heart recipient.
.P
JOURNAL ARTICLE.
.A
Murray KD; Abbott T; DeVries WC; Gaykowski R; Olsen DB.
.I 82
.U
87049353
.S
ASAIO Trans 8703; 32(1):425-8
.M
Adsorption; Biocompatible Materials; Blood Proteins/*IP; Charcoal/*; Hemodialysis/*; Hemoperfusion/*; Human; Kidney Failure, Chronic/TH; Molecular Weight; Polyurethanes.
.T
Elimination of low molecular weight proteins during hemoperfusion of dialysis patients using a urethane-sheet embedded with powdered charcoal.
.P
JOURNAL ARTICLE.
.A
Kawanishi H; Tsuchiya T; Sugiyama M; Nishiki M; Dohi K.
.I 83
.U
87049354
.S
ASAIO Trans 8703; 32(1):429-34
.M
Animal; Biocompatible Materials; Blood Component Removal/*/IS/MT; Dextrans; Dogs; Filtration/MT; Human; Hypercholesterolemia/BL/TH; Membranes, Artificial; Molecular Weight; Plasma/*; Support, Non-U.S. Gov't.
.T
Effect of plasma solute-membrane interaction on mean pore diameter.
.P
JOURNAL ARTICLE.
.A
Horiuchi T; Malchesky PS; Usami M; Emura M; Nose Y.
.I 84
.U
87049357
.S
ASAIO Trans 8703; 32(1):444-8
.M
Animal; Ceramics/*; Comparative Study; Heart Valve Prosthesis/*; Materials Testing/*; Sheep; Support, Non-U.S. Gov't; Venae Cavae/PH.
.T
Development of a fine ceramic heart valve for use as a cardiac prosthesis.
.P
JOURNAL ARTICLE.
.A
Mitamura Y; Mikami T; Yuta T; Matsumoto T; Shimooka T; Okamoto E; Eizuka N; Yamaguchi K.
.I 85
.U
87049360
.S
ASAIO Trans 8703; 32(1):46-8
.M
Animal; Assisted Circulation/*IS; Cattle; Heart Rate; Heart-Assist Devices/*IS/MT; Hemoglobins/AN; Male; Postoperative Care; Support, Non-U.S. Gov't; Time Factors.
.T
Roller screw electric motor ventricular assist device.
.P
JOURNAL ARTICLE.
.W
The roller screw electric VAD is easier to manufacture and 25% lighter than the previously described drum cam model. This device requires 12 to 15 W to pump 6 to 8 l/min with minimal hemolysis. The motor drive has functioned for periods up to 93 days in vivo with no measurable wear. The compliance chamber volume varies by 100 cc during VAD function but does so while maintaining pressure variations below 15 mmHg. Compliance chamber volume loss of 2 to 5 cc/day is explained by gas transport through SPU. The subcutaneous sampling port provides ready access to the sealed system.
.A
Richenbacher WE; Pae WE Jr; Magovern JA; Rosenberg G; Snyder AJ; Pierce WS.
.I 86
.U
87049361
.S
ASAIO Trans 8703; 32(1):461-6
.M
Adult; Aged; Assisted Circulation/*; Case Report; Child, Preschool; Echocardiography/*; Female; Heart/*PP; Heart Surgery/*; Heart-Assist Devices/*; Hemodynamics; Human; Male; Middle Age; Monitoring, Physiologic/*; Postoperative Complications/TH.
.T
Natural heart recovery under left ventricular assist device pumping studied by echocardiography.
.P
JOURNAL ARTICLE.
.A
Nakatani T; Takano H; Beppu S; Noda H; Fukuda S; Fujita T; Akutsu T; Nimura Y; Manabe H.
.I 87
.U
87049363
.S
ASAIO Trans 8703; 32(1):474-7
.M
Animal; Axons/UL; Collagen/PH; Extracellular Matrix/*PH; Female; Glycoproteins/PH; Heparitin Sulfate/PH; Implants, Artificial/*; Laminin/PH; Membranes, Artificial; Mice; Microscopy, Electron; Myelin Sheath/UL; Nerve Regeneration/*; Sciatic Nerve/CY/*PH/UL.
.T
Regeneration of transected sciatic nerves through semi-permeable nerve guidance channels. Effects of extracellular matrix protein additives.
.P
JOURNAL ARTICLE.
.A
Aebischer P; Valentini RF; Winn SR; Kunz S; Sasken H; Galletti PM.
.I 88
.U
87049365
.S
ASAIO Trans 8703; 32(1):482-5
.M
Animal; Antibody Formation; Drug Hypersensitivity/*; Ethylene Oxide/*TO; Female; Hemodialysis; Human; IgE/AN; Male; Mice; Mice, Inbred Strains; Passive Cutaneous Anaphylaxis/*; Rats; Rats, Inbred Strains.
.T
Animal model for ethylene oxide (EtO) associated hypersensitivity reactions.
.P
JOURNAL ARTICLE.
.A
Chapman J; Lee W; Youkilis E; Martis L.
.I 89
.U
87049366
.S
ASAIO Trans 8703; 32(1):486-9
.M
Adolescence; Aged; Blood Proteins/AN; Case Report; Chronic Disease; Complement/AN; Demyelinating Diseases/*TH; Female; Follow-Up Studies; Human; Immunoglobulins/AN; Inflammation; Male; Plasma/*; Polyradiculoneuritis/*TH; Ultrafiltration/*/IS/MT.
.T
Treatment of chronic inflammatory demyelinating polyradiculoneuropathy by plasma filtration.
.P
JOURNAL ARTICLE.
.A
Abe Y; Baba M; Baba T; Tamasawa N; Kurahashi K; Hirai Y; Nakahata H; Matsunaga M; Takebe K.
.I 90
.U
87049367
.S
ASAIO Trans 8703; 32(1):49-51
.M
Aged; Blood/*; Heparin/TU; Human; Middle Age; Suction; Support, Non-U.S. Gov't; Ultrafiltration/*MT; Urea/BL; Vacuum.
.T
Clinical trials with predilution and vacuum suction: enhancing the efficiency of the CAVH treatment.
.P
JOURNAL ARTICLE.
.A
Kaplan AA.
.I 91
.U
87049368
.S
ASAIO Trans 8703; 32(1):490-4
.M
Alanine Aminotransferase/BL; Animal; Aspartate Aminotransferase/BL; Blood Coagulation Tests; Creatinine/BL; Dogs; Electrolytes/BL; Erythrocyte Count; Erythrocytes/AN; Exchange Transfusion, Whole Blood/*; Hematocrit/*; Hemoglobins/*/*AN; Platelet Count; Polyethylene Glycols/*; Solutions; Support, Non-U.S. Gov't; Urea/BL.
.T
Physiologic effects of pyridoxalated-hemoglobin-polyethylene glycol conjugate solution in exchange transfusion.
.P
JOURNAL ARTICLE.
.A
Matsushita M; Iwashita Y; Iwasaki K; Ohki H; Nasu M; Horiuchi T; Chen JF; Goldcamp J; Murabayashi S; Harasaki H; et al.
.I 92
.U
87049369
.S
ASAIO Trans 8703; 32(1):495-9
.M
Aged; Blood/*; Blood Proteins/AN; Case Report; Cryoglobulins/*IP/ME; Female; Human; Immunoglobulins/AN; Sjogren's Syndrome/BL/*TH; Ultrafiltration/*/IS/MT.
.T
Clinical evaluation of a multilayered cryofilter for highly selective cryoglobulin removal.
.P
JOURNAL ARTICLE.
.A
Emura M; Horiuchi T; Malchesky PS; Goldcamp JB; Usami M; Sakamoto H; Matsushita M; Suzuki M; Nose Y.
.I 93
.U
87049371
.S
ASAIO Trans 8703; 32(1):500-2
.M
Blood Pressure; Catheters, Indwelling/*ST; Hemodialysis/*ST; Human; Kidney Failure, Acute/*PP/TH; Kidney Failure, Chronic/*PP/TH; Polyurethanes; Quality Control; Support, Non-U.S. Gov't.
.T
Minimum performance standards for double-lumen subclavian cannulas for hemodialysis.
.P
JOURNAL ARTICLE.
.A
Bregman H; Miller K; Berry L.
.I 94
.U
87049374
.S
ASAIO Trans 8703; 32(1):511-4
.M
Catheters, Indwelling; Diabetes Mellitus, Insulin-Dependent/DT; Equipment Failure/*; Follow-Up Studies; Human; Insulin Infusion Systems/*.
.T
Implantable continuous intravenous insulin infusion device. Restoration of flow after slow-down.
.P
JOURNAL ARTICLE.
.A
Kernstine KH; Kryjeski SR; Wigness BD; Goldenberg FJ; Rohde TD; Dorman FD; Chute EP; Rupp WM; Buchwald H.
.I 95
.U
87049375
.S
ASAIO Trans 8703; 32(1):515-20
.M
Animal; Dogs; Fibrinogen/AN; Implants, Artificial/*AE; Microscopy, Electron, Scanning; Oxidation-Reduction; Platelet Aggregation; Polyethylenes/*AE; Regional Blood Flow/*; Support, U.S. Gov't, P.H.S.; Thrombosis/*ET.
.T
Blood flow and surface-induced thrombosis.
.P
JOURNAL ARTICLE.
.A
Grasel TG; Wilson RS; Lelah MD; Bielich HW; Cooper SL.
.I 96
.U
87049376
.S
ASAIO Trans 8703; 32(1):52-7
.M
Aluminum/*BL/IP; Blood Proteins/AN; Deferoxamine/*TU; Hemodialysis/*MT; Human; Kinetics; Permeability; Time Factors.
.T
Removal of aluminum from chronic dialysis patients by administration of desferrioxamine and dialysis.
.P
JOURNAL ARTICLE.
.W
In order to perform quantitative in vitro and clinical studies on the removal of Al by the combined therapy of DFO administration and HD, an HPLC system for measuring DFO was established and a leaky membrane with enhanced permeability to middle molecular substances was developed. The DFO infusion caused rises in plasma Al levels (regarded as indicating the elution of accumulated Al) in patients undergoing HD. Plasma levels increased most in long-term patients and those with bone pain. Examination of Al clearances demonstrated that this increased plasma Al content passed through HD membranes at levels of more than 80 micrograms/l, and that the leaky membrane was more effective for removal of Al as well as DFO than the conventional one. Although a 1:1 complex between DFO and Al in an aqueous solution was confirmed, the formation of Al-rich complexes in vivo was suggested. It is concluded that Al-DFO complex formed in vivo can be effectively removed across the leaky membrane.
.A
Ono T; Iwamoto N; Kataoka H; Taniguchi Y; Sakai Y; Kunitomo T.
.I 97
.U
87049377
.S
ASAIO Trans 8703; 32(1):521-4
.M
Animal; Artificial Organs/*; Cardiopulmonary Bypass/*IS; Dogs; Extracorporeal Circulation/IS; Hemodynamics; Lung/*PH; Membranes, Artificial.
.T
A portable, pumpless, AV bypass ECCO2R system, with a hollow fiber membrane lung.
.P
JOURNAL ARTICLE.
.A
Fukui Y; Kawamura T.
.I 98
.U
87049380
.S
ASAIO Trans 8703; 32(1):534-7
.M
Extracorporeal Circulation/*AE; Female; Human; Infant, Newborn; Infant, Newborn, Diseases/BL/*TH; Male; Oxygen/*BL; Partial Pressure; Respiratory Distress Syndrome/BL/*TH; Thrombocytopenia/*ET.
.T
Thrombocytopenia in neonates after extracorporeal membrane oxygenation.
.P
JOURNAL ARTICLE.
.A
Anderson HL 3d; Cilley RE; Zwischenberger JB; Bartlett RH.
.I 99
.U
87049381
.S
ASAIO Trans 8703; 32(1):538-41
.M
Acute Disease; Animal; Assisted Circulation/*; Blood Pressure; Cardiac Output; Comparative Study; Dogs; Extracorporeal Circulation/*; Heart/*PP; Heart Diseases/*TH; Heart Ventricle/PP; Heart-Assist Devices/*.
.T
Vented cardiac assistance: ECMO versus left heart bypass for acute left ventricular failure.
.P
JOURNAL ARTICLE.
.A
Eugene J; Ott RA; McColgan SJ; Roohk HV.
.I 100
.U
87049383
.S
ASAIO Trans 8703; 32(1):546-9
.M
Adolescence; Adult; Aged; Female; Human; Male; Middle Age; Morbidity; Ontario; Peritoneal Dialysis, Continuous Ambulatory/*AE; Peritonitis/EP/*ET/PC; Staphylococcal Infections/EP/*ET/PC; Staphylococcus aureus; Staphylococcus epidermidis; Support, Non-U.S. Gov't.
.T
The CAPD peritonitis rate is not improving with time.
.P
JOURNAL ARTICLE.
.A
Fenton SS; Pei Y; Delmore T; Cattran DC; Bowman C; Johnston N; Campbell I; Clarke WT; Richardson RM.
.I 101
.U
87049384
.S
ASAIO Trans 8703; 32(1):550-3
.M
Animal; Glucose/*; Milk Proteins; Osmolar Concentration; Peptides/*; Peritoneal Dialysis/*MT; Protein Hydrolysates/*; Rabbits.
.T
Peptides as substitute osmotic agents for glucose in peritoneal dialysate.
.P
JOURNAL ARTICLE.
.A
Klein E; Ward RA; Williams TE; Feldhoff PW.
.I 102
.U
87049385
.S
ASAIO Trans 8703; 32(1):554-6
.M
Adult; Heart/*PP; Heart Ventricle/PP; Human; Infusions, Parenteral; Kidney Failure, Chronic/PP/*TH; Myocardial Contraction/*; Peritoneal Dialysis, Continuous Ambulatory/*MT; Posture; Systole/*.
.T
Effect of intraperitoneal infusion volume and posture on left ventricular systolic function in patients on continuous ambulatory peritoneal dialysis.
.P
JOURNAL ARTICLE.
.A
Franklin JO; Alpert MA; Twardowski ZJ; Khanna R.
.I 103
.U
87049386
.S
ASAIO Trans 8703; 32(1):557-9
.M
Adult; Diabetic Nephropathies/TH; Female; Glomerulonephritis/CO; Human; Kidney Failure, Chronic/ET/*TH; Male; Patient Education; Peritoneal Dialysis, Continuous Ambulatory/AE/*IS; Peritonitis/PC; Quality Control; Support, Non-U.S. Gov't; United States.
.T
A multicenter trial to evaluate the use of the CAPD "O" set.
.P
JOURNAL ARTICLE.
.A
Lempert KD; Kolb JA; Swartz RD; Campese V; Golper TA; Winchester JF; Nolph KD; Husserl FE; Zimmerman SW; Kurtz SB; et al.
.I 104
.U
87049387
.S
ASAIO Trans 8703; 32(1):560-3
.M
California; Demography; Follow-Up Studies; Human; Kidney Failure, Chronic/*TH; Nevada; Peritoneal Dialysis, Continuous Ambulatory/*/AE; Peritonitis/ET.
.T
Long-term outcome of continuous ambulatory peritoneal dialysis. The Southern California/Southern Nevada experience.
.P
JOURNAL ARTICLE.
.A
Nissenson AR; Gentile DE; Soderblom RE; Brax C.
.I 105
.U
87049388
.S
ASAIO Trans 8703; 32(1):564-6
.M
Animal; Diltiazem/*PD; Glucose/*ME; Male; Peritoneal Dialysis/*; Proteins/*ME; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Urea/*ME; Verapamil/*PD.
.T
Effects of calcium channel blockers (verapamil, diltiazem) on peritoneal transport.
.P
JOURNAL ARTICLE.
.A
Lal SM; Nolph KD; Moore HL; Khanna R.
.I 106
.U
87049389
.S
ASAIO Trans 8703; 32(1):567-71
.M
Blood/*; Human; Kidney Failure, Chronic/*TH; Kidney, Artificial/*; Membranes, Artificial; Models, Biological; Nephrons/PH; Ultrafiltration/*/IS/MT.
.T
Continuous arterio-venous hemofiltration in a wearable device to treat end-stage renal disease.
.P
JOURNAL ARTICLE.
.A
Murisasco A; Reynier JP; Ragon A; Boobes Y; Baz M; Durand C; Bertocchio P; Agenet C; el Mehdi M.
.I 107
.U
87049390
.S
ASAIO Trans 8703; 32(1):572-4
.M
Adolescence; Adult; Aged; Disposable Equipment; Evaluation Studies; Female; Human; Kidney Failure, Chronic/TH; Male; Middle Age; Peritoneal Dialysis, Continuous Ambulatory/*IS; Support, Non-U.S. Gov't.
.T
Multicenter evaluation of a bagless CAPD system.
.P
JOURNAL ARTICLE.
.A
Suki WN; Walshe JJ; Ashbrook DW; Gentile DE; Tucker CT; Ash SR; Ahmad S.
.I 108
.U
87049391
.S
ASAIO Trans 8703; 32(1):575-80
.M
Adult; Aged; Aged, 80 and over; Comparative Study; Creatinine/ME; Female; Glucose/ME; Human; Kidney Failure, Chronic/*ME/TH; Kinetics; Male; Middle Age; Peritoneal Dialysis/*; Peritoneal Dialysis, Continuous Ambulatory/*; Phosphates/ME; Potassium/ME; Sodium/ME; Support, Non-U.S. Gov't; Urea/ME.
.T
Daily clearances with continuous ambulatory peritoneal dialysis and nightly peritoneal dialysis.
.P
JOURNAL ARTICLE.
.A
Twardowski ZJ; Nolph KD; Khanna R; Gluck Z; Prowant BF; Ryan LP.
.I 109
.U
87049392
.S
ASAIO Trans 8703; 32(1):58-63
.M
Blood Substitutes/*AD; Half-Life; Hemoglobins/*AD/ME/TU; Human; Kinetics; Liposomes/*AD; Oxygen/BL; Phosphatidylcholines/*; Support, U.S. Gov't, Non-P.H.S..
.T
Liposome-encapsulated hemoglobin as a red cell surrogate. Preparation scale-up.
.P
JOURNAL ARTICLE.
.A
Beissinger RL; Farmer MC; Gossage JL.
.I 110
.U
87049393
.S
ASAIO Trans 8703; 32(1):581-2
.M
Air/*; Diaphragm/*RA; Human; Peritoneal Dialysis, Continuous Ambulatory/*/AE; Posture.
.T
Is air under the diaphragm a significant finding in CAPD patients?
.P
JOURNAL ARTICLE.
.W
The incidence of air under the diaphragm in CAPD patients is very low, and causes directly attributable to standard CAPD techniques are even lower. Bowel perforation generally causes a larger volume of air collection under the diaphragm.
.A
Lampainen E; Khanna R; Schaefer R; Twardowski ZJ; Nolph KD.
.I 111
.U
87049394
.S
ASAIO Trans 8703; 32(1):583-6
.M
Antigens, Neoplasm/*IP; Breast Neoplasms/IM; Extracorporeal Circulation/IS/*MT; Female; Human; Immunosuppression; Male; Neoplasms/*IM; Plasmapheresis; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S..
.T
Extracorporeal removal of tumor antigens.
.P
JOURNAL ARTICLE.
.A
Shettigar UR; Kolff WJ; Gregonis D.
.I 112
.U
87049395
.S
ASAIO Trans 8703; 32(1):587-90
.M
Animal; Calcinosis/PA/*PC; Cattle; Delayed-Action Preparations; Diphosphonates/*TU; Heart Valve Prosthesis/*; Male; Microscopy, Electron, Scanning; Rats; Silicone Elastomers; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S..
.T
Inhibition of bioprosthetic heart valve calcification by sustained local delivery of Ca and Na diphosphonate via controlled release matrices.
.P
JOURNAL ARTICLE.
.A
Golomb G; Dixon M; Smith MS; Schoen FJ; Levy RJ.
.I 113
.U
87049396
.S
ASAIO Trans 8703; 32(1):591-6
.M
Animal; Blood Platelets/*CY; Cattle; Fibrin/*AN; Fibrinogen/*AN; Heart Valve Prosthesis/*/AE; Indium/DU; Iodine Radioisotopes/DU; Radioisotopes/DU; Support, U.S. Gov't, P.H.S.; Thrombosis/*ET; Time Factors; Tropolone/AA/DU.
.T
Quantitation of platelet and fibrinogen-fibrin deposition on components of tissue valves (Ionescu-Shiley) in calves.
.P
JOURNAL ARTICLE.
.W
With 111In-labeled platelets and 125I-labeled bovine fibrinogen, regional mapping of platelet and fibrinogen deposition on leaflets and sewing rings was obtained. Ten Holstein calves received 25-mm mitral valves (ISLM) and were killed 1, 14, and 30 days after implantation. Twenty-four hours before the calves were killed, 350 to 450 microCi of 111In-labeled platelets and 200 to 250 microCi of 125I-labeled bovine fibrinogen were administered intravenously. The components of the tissue valves, i.e., three leaflets and sewing rings, were separated. Each leaflet was cut into four sections: free edge, central zone, flexion zone, and attachment zone. From the radioactivity in blood, leaflet zones, sewing rings, area of leaflet zones, platelet count, and fibrinogen level in blood, the mean regional density of adherent platelets, fibrinogen-fibrin, and fibrinogen/platelet were calculated. The density of platelets and fibrinogen deposited on the components of the valves decreases with time postimplantation. The number of fibrinogen molecules per platelet is fivefold to 20-fold higher than that of the receptor concentration on platelets on leaflet zones, suggesting the heterogeneity of fibrinogen-fibrin in thrombus and components of the valve.
.A
Dewanjee MK; Solis E; Lenker J; Tidwell C; Mackey S; Didisheim P; Kaye MP.
.I 114
.U
87049397
.S
ASAIO Trans 8703; 32(1):597-600
.M
Adult; Human; In Vitro; Lipid A/*PD; Lipopolysaccharides/*PD; Luminescence; Neutrophils/CY/DE/*PH; Salmonella/*IM; Support, Non-U.S. Gov't.
.T
Neutrophil stimulation by lipid A and lipopolysaccharides from Salmonella minnesota.
.P
JOURNAL ARTICLE.
.A
DeBari VA; Uychich PM; Orsini AJ; Ingenito AC; Needle MA.
.I 115
.U
87049398
.S
ASAIO Trans 8703; 32(1):601-4
.M
Animal; Arteries/SU; Blood Vessel Prosthesis/*; Dogs; Femoral Artery/SU; Microscopy, Electron, Scanning; Silicone Elastomers; Support, U.S. Gov't, P.H.S.; Vascular Patency/*.
.T
Maintenance of compliance in a small diameter arterial prosthesis.
.P
JOURNAL ARTICLE.
.W
This study demonstrates that 20 to 30 microns porous, Replamineform silicone rubber prostheses remain isocompliant with adjacent arterial segments up to 8 months following implantation. This finding contrasts with the results of currently available prostheses, including autologous vein, which rapidly become minimally compliant. We conclude that this vascular construction is stable over the long-term following implantation and may improve the success of small internal diameter arterial reconstruction by eliminating failures caused by intimal hyperplasia.
.A
White RA; Klein SR; Shors E.
.I 116
.U
87049399
.S
ASAIO Trans 8703; 32(1):605-8
.M
Animal; Elasticity; Implants, Artificial/*; Microscopy, Electron, Scanning; Polyvinyl Alcohol/*; Prosthesis; Prosthesis Design; Rabbits; Tensile Strength.
.T
A new hydrogel and its medical application.
.P
JOURNAL ARTICLE.
.A
Tamura K; Ike O; Hitomi S; Isobe J; Shimizu Y; Nambu M.
.I 117
.U
87049400
.S
ASAIO Trans 8703; 32(1):609-11
.M
Animal; Biopsy; Factor XIII/*; Gelatin/*; Hemostasis/*; Heparin; Liver/CY; Male; Rats; Rats, Inbred Strains; Support, Non-U.S. Gov't; Thrombin/*; Wound Healing/*.
.T
A new hemostatic material, G.T.XIII.
.P
JOURNAL ARTICLE.
.A
Sugitachi A; Kato M; Masuzawa M; Terada A.
.I 118
.U
87049401
.S
ASAIO Trans 8703; 32(1):64-7
.M
Adult; Aged; Catheterization/MT; Catheters, Indwelling/*; Comparative Study; Female; Follow-Up Studies; Human; Male; Middle Age; Peritoneal Dialysis/*; Support, Non-U.S. Gov't.
.T
Preliminary experience with the Swan Neck peritoneal dialysis catheters.
.P
JOURNAL ARTICLE.
.A
Twardowski ZJ; Khanna R; Nolph KD; Nichols WK; Ryan LP.
.I 119
.U
87049402
.S
ASAIO Trans 8703; 32(1):68-70
.M
Adult; Bilirubin/*BL/IP; Case Report; Female; Human; Infant, Newborn; Infant, Premature/*; Jaundice, Neonatal/BL/*TH; Resins; Support, Non-U.S. Gov't; Ultrafiltration/*MT.
.T
Bilirubin removal from a jaundiced premature infant by resin hemoperfusion.
.P
JOURNAL ARTICLE.
.W
To summarize the results: Bilirubin removal by hemoperfusion was successfully performed for the first time on a premature infant. The hemoperfusion caused no adverse effects on the clinical state of the infant. The bilirubin removed in 90 min--13 mg--indicates the existence of a large extravascular pool. Hemoperfusion is suggested for bilirubin removal from newborn babies, reducing the need for blood exchange with bank blood.
.A
Brandes JM; Mor L; Sideman S; Zeltzer M; Sujov P; Blazer S.
.I 120
.U
87049404
.S
ASAIO Trans 8703; 32(1):76-80
.M
Cellulose/*; Complement Activation; Hemodialysis/*MT; Human; Leukocyte Count; Membranes, Artificial/*; Platelet Count; Surface Properties.
.T
Development of a regenerated cellulose non-complement activating membrane for hemodialysis.
.P
JOURNAL ARTICLE.
.W
We have developed a new cellulose membrane in which the active hydroxyl and carboxyl groups of the original cellulose fibers are masked with cationic synthetic polymers. The membrane was shown by in vitro and clinical tests to affect the activation of the complement system very little, and it retains the high dialysis efficiency, good tolerance to steam autoclave sterilization, and economical production cost characteristics of the original cellulose membrane. It thus appears that the new cellulose provides the optimum combination of qualities needed in a hemodialysis membrane.
.A
Akizawa T; Kitaoka T; Koshikawa S; Watanabe T; Imamura K; Tsurumi T; Suma Y; Eiga S.
.I 121
.U
87049405
.S
ASAIO Trans 8703; 32(1):81-4
.M
Antibodies, Monoclonal/*TU; Antigen-Antibody Complex/*; Autoimmune Diseases/*TH; Human; Kinetics; Membranes, Artificial/*.
.T
A membrane-immobilized monoclonal antibody immunoadsorption system.
.P
JOURNAL ARTICLE.
.A
McManus DE; Randerson DH.
.I 122
.U
87049408
.S
ASAIO Trans 8703; 32(1):93-7
.M
Aged; Ascitic Fluid/*TH; Case Report; Diabetic Nephropathies/TH; Female; Hemodialysis; Human; Kidney Failure, Chronic/ET/TH; Male; Middle Age; Peritoneovenous Shunt/IS/*MT.
.T
External peritoneo-venous shunt for intractable ascites.
.P
JOURNAL ARTICLE.
.A
Inagaki Y; Amano I.
.I 123
.U
87049453
.S
Br J Anaesth 8703; 58(11):1207-9
.M
Animal; Disease Models, Animal; Human; Respiratory Distress Syndrome, Adult/DI/*ET/TH; Sheep.
.T
Acute/adult/animal respiratory distress syndrome [editorial]
.P
EDITORIAL.
.A
Royston D.
.I 124
.U
87049454
.S
Br J Anaesth 8703; 58(11):1210-3
.M
Anesthesia, Inhalation; Atracurium/*ME; Child; Child, Preschool; Human; Infant; Isoflurane; Isoquinolines/BL; Kinetics; Liver/PP; Liver Diseases/BL/*ME/PP; Nitrous Oxide; Support, Non-U.S. Gov't.
.T
Pharmacokinetics of atracurium in anaesthetized infants and children.
.P
JOURNAL ARTICLE.
.W
The pharmacokinetics of atracurium were studied in infants and children anaesthetized with isoflurane and nitrous oxide in oxygen. There were no significant differences in volume of distribution (area) (139 v. 152 ml kg-1), clearance (5.1 v. 5.3 ml kg-1 min-1), T1/2 alpha (2.1 v. 2.0 min), or T1/2 beta (19.1 v. 20.3 min) between children with normal hepatic and renal function and those with moderately impaired hepatic function presenting for hepatic transplantation. There were significant differences in volume of distribution (area) (176 v. 139 ml kg-1) and in clearance of atracurium (9.1 v. 5.1 ml kg-1 min-1) between infants and children with normal excretory function. In infants the clearance of atracurium in ml m-2 min-1 (153 v. 133) tended to be greater and the T1/2 alpha and T1/2 beta tended to be shorter (1.0 v. 2.0 and 13.6 v. 19.1) than in children with normal excretory function; however, these trends did not reach statistical significance. Plasma laudanosine concentration was around 100 ng ml-1 greater in patients with liver disease than in normal children from 15-45 min following a bolus of atracurium 0.5 mg kg-1.
.A
Brandom BW; Stiller RL; Cook DR; Woelfel SK; Chakravorti S; Lai A.
.I 125
.U
87049455
.S
Br J Anaesth 8703; 58(11):1214-7
.M
Anesthesia, Intratracheal; Atracurium/AD/*PD; Biliary Atresia/PP/*SU; Drug Administration Schedule; Female; Human; Infant; Infant, Newborn; Intraoperative Care; Liver/*PP; Male; Neuromuscular Blocking Agents/*.
.T
Use of atracurium during major abdominal surgery in infants with hepatic dysfunction from biliary atresia.
.P
JOURNAL ARTICLE.
.W
The use of atracurium during major abdominal surgery was assessed in 20 infants with hepatic dysfunction caused by biliary atresia. An initial dose of 0.6 mg kg-1 provided excellent intubating conditions in all patients. Subsequent neuromuscular blockade was monitored with a peripheral nerve stimulator and incremental doses of atracurium were given on reappearance of a single twitch. Neuromuscular conduction was allowed to return at the end of surgery and by careful timing of increments it was necessary to antagonize the neuromuscular blockade in only two patients.
.A
Simpson DA; Green DW.
.I 126
.U
87049457
.S
Br J Anaesth 8703; 58(11):1224-8
.M
Adolescence; Anesthesia, Inhalation/*AE; Child; Child, Preschool; Female; Halothane/AD/*AE; Hepatitis, Toxic/*ET/PP; Human; Infant; Liver/*DE/PP; Male; Postoperative Period; Prospective Studies; Support, Non-U.S. Gov't; Time Factors.
.T
Prospective study of liver function in children following multiple halothane anaesthetics at short intervals.
.P
JOURNAL ARTICLE.
.W
In the 4 years January 1981 to December 1984, 186 children received 1362 halothane anaesthetics. Twenty-five patients were anaesthetized with halothane at least 10 times in a year. No patient developed postoperative jaundice. Sixty-nine children were exposed to two halothane anaesthetics within 28 days on 149 occasions and serial estimations of serum liver enzyme concentrations were obtained. Minor increases in the concentrations of serum AST and ALT were recorded in 10.6% and 4.7% of patient entries, respectively. Postoperative GGT and SAP concentrations were increased in 2.7% of patient entries. Patients in whom enzyme values were increased before the first anaesthetic were no more likely than other subjects to develop further changes.
.A
Wark H; O'Halloran M; Overton J.
.I 127
.U
87049458
.S
Br J Anaesth 8703; 58(11):1229-33
.M
Atracurium/*PD; Child; Child, Preschool; Female; Histamine/BL; Histamine Liberation/*DE; Human; Infant; Male; Neuromuscular Junction/DE; Time Factors; Vecuronium/*PD.
.T
Histamine release during the administration of atracurium or vecuronium in children.
.P
JOURNAL ARTICLE.
.W
The histamine releasing potential of equivalent bolus doses of atracurium 0.6 mg kg-1 or vecuronium 0.12 mg kg-1 was evaluated in 20 children anaesthetized with halothane. Blood samples were obtained before, and at 2 and 5 min after the administration of the neuromuscular blocker. The twitch response to 0.15 Hz was also evaluated. None of the 10 patients receiving vecuronium had a significant increase in plasma histamine concentration. In two of the 10 children receiving atracurium, the plasma histamine concentration increased markedly, but without any apparent clinical manifestations. Recovery of neuromuscular function (to 95% twitch height) after vecuronium 0.12 mg kg-1 was faster than after atracurium 0.6 mg kg-1 (P less than 0.02).
.A
Goudsouzian NG; Young ET; Moss J; Liu LM.
.I 128
.U
87049459
.S
Br J Anaesth 8703; 58(11):1234-41
.M
Adrenocorticotropic Hormone/BL; Anesthesia, Inhalation; Catecholamines/BL; Child; Child, Preschool; Halothane; Hormones/*BL; Human; Hydrocortisone/BL; Infant; Midazolam/*PD; Postoperative Period; Premedication/*; Pulmonary Gas Exchange; Respiration/*DE; Support, Non-U.S. Gov't; Surgery, Operative.
.T
Ventilation, ventilatory carbon dioxide and hormonal response during halothane anaesthesia and surgery in children after midazolam premedication.
.P
JOURNAL ARTICLE.
.W
In 14 intubated, spontaneously breathing children with body weight (bw) ranging from 8.3 to 25.6 kg, the influence of midazolam 0.1 mg kg-1 i.m. (group M0.1, n = 7) and 0.2 mg kg-1 i.m. (group M0.2, n = 7) as premedication, on sedation, ventilation, ventilatory response to carbon dioxide and hormonal stress response was studied in connection with minor surgical procedures during halothane anaesthesia. The concentrations of catecholamines, ACTH and cortisol were measured immediately after induction, during undisturbed anaesthesia, during surgery and 15 min after the end of the surgical procedure. Sedation was better and plasma catecholamine concentrations during undisturbed anaesthesia were less in children receiving the larger dose of midazolam. During surgery and in recovery there were no differences in hormone concentrations. In recovery, the concentrations of all hormones were significantly greater compared with during undisturbed anaesthesia. During surgery, VE and respiratory rate were somewhat lower in group M0.2 while E' CO2 was similar. A dose dependent depression of the response to carbon dioxide was found. However, clinically, the ventilatory response to carbon dioxide after surgery was considered to be adequate in both groups.
.A
Charlton AJ; Hatch DJ; Lindahl SG; Phythyon JM; Norden NE.
.I 129
.U
87049466
.S
Br J Anaesth 8703; 58(11):1278-84
.M
Adult; Alcuronium/AI/*PD; Atracurium/AI/*PD; Comparative Study; Electromyography; Evoked Potentials/DE; Human; Muscle Contraction/DE; Muscles/*DE; Neostigmine/*PD; Neuromuscular Blocking Agents/*; Toxiferine/*AA.
.T
Evoked electromyographic and mechanical responses of the adductor pollicis compared during the onset of neuromuscular blockade by atracurium or alcuronium, and during antagonism by neostigmine.
.P
JOURNAL ARTICLE.
.W
The effects of atracurium and alcuronium on the evoked mechanical and electromyographic responses of the adductor pollicis were investigated in 30 adult patients. The ulnar nerve was stimulated with trains of four supramaximal pulses of 0.2 ms duration and a frequency of 2 Hz at intervals of 20 s. The mechanical response was measured using a strain gauge force transducer and the evoked compound action potential (ECAP) was recorded simultaneously using a Medelec MS91 electromyography system. Depression of the electromyographic and mechanical responses, caused by atracurium, was similar during onset and antagonism of blockade. During onset of blockade by alcuronium, the mechanical response was depressed to a significantly greater extent compared with the ECAP. This difference was not observed during antagonism with neostigmine. The rates of onset of atracurium and alcuronium were generally similar, but the rate of onset of mechanical fade was greater in the alcuronium group. There was no significant quantitative difference between the rates of antagonism of alcuronium and atracurium when assessed by the mechanical first response ratio. Electromyographic first response and electromyographic and mechanical train-of-four ratios recovered more rapidly in the atracurium group. These findings suggest that the differences between mechanical and electromyographic measurements of neuromuscular blockade are drug-specific and are more pronounced during the onset of blockade than during its antagonism by neostigmine.
.A
Harper NJ; Bradshaw EG; Healy TE.
.I 130
.U
87049467
.S
Br J Anaesth 8703; 58(11):1285-9
.M
Adult; Atracurium/*AI; Comparative Study; Edrophonium/*PD; Human; Middle Age; Muscle Contraction/DE; Neostigmine/*PD; Neuromuscular Blocking Agents/*AI; Time Factors; Vecuronium/*AI.
.T
Antagonism of profound neuromuscular blockade induced by vecuronium or atracurium. Comparison of neostigmine with edrophonium.
.P
JOURNAL ARTICLE.
.W
The effectiveness of neostigmine 0.07 mg kg-1 and edrophonium 0.8 mg kg-1 as antagonists of profound neuromuscular blockade induced by vecuronium 0.1 mg kg-1 or atracurium 0.5 mg kg-1 was studied in 59 healthy patients. The antagonists were administered 5 min after total ablation of the twitch response and the end-point of recovery was a train-of-four ratio of 70%. In 30 patients given vecuronium the mean time to reach this point (duration TOF70) was 66.7 min in the control group (no antagonist), 43.5 min in the group given neostigmine and 59.8 min in the group given edrophonium. The duration TOF70 was shorter in the neostigmine group than in the control (P less than 0.01) and edrophonium (P less than 0.01) groups. The duration TOF70 did not differ from control in the edrophonium group. In 29 patients given atracurium, the durations TOF70 were 66.4, 44.1 and 54.9 min in the control, neostigmine and edrophonium groups, respectively. The durations TOF70 in the neostigmine (P less than 0.01) and edrophonium (P less than 0.01), groups were shorter than control. The duration TOF70 of the neostigmine group was shorter than in the edrophonium group (P less than 0.01). These results show that profound neuromuscular blockade cannot be rapidly antagonized by either of these two agents, but if reversal is required under these circumstances, neostigmine would be the more effective drug.
.A
Caldwell JE; Robertson EN; Baird WL.
.I 131
.U
87049468
.S
Br J Anaesth 8703; 58(11):1290-5
.M
Atracurium/*AI/PD; Comparative Study; Edrophonium/*PD; Human; Muscle Contraction/DE; Neostigmine/*PD; Neuromuscular Blocking Agents/*AI; Time Factors.
.T
Antagonism of atracurium-induced neuromuscular blockade by neostigmine or edrophonium.
.P
JOURNAL ARTICLE.
.W
Antagonism of atracurium-induced neuromuscular blockade by neostigmine or edrophonium has been studied using the tetanic (50 Hz) and train-of-four (2 Hz) or single twitch responses of the adductor pollicis muscle in 22 anaesthetized patients. A further nine patients not given an anticholinesterase acted as a control group. In two groups (six patients for each anticholinesterase) in whom antagonism was attempted at 95-98% blockade of the tetanic response, recovery of the tetanic response after two or three doses of edrophonium 0.75 mg kg-1 i.v. was not statistically different from that in the control group; recovery after two doses of neostigmine 2.5 mg i.v. was significantly faster (P less than 0.001). Recovery of the single twitch response after antagonism with edrophonium, although longer than that with neostigmine (P less than 0.01), was significantly shorter than in the control group (P less than 0.05). When edrophonium is given at the commencement of recovery, the initial rapid antagonism of tetanic block is not sustained, whereas antagonism by neostigmine is more persistent and the recovery phase is significantly shortened. In a further two groups of patients (n = 5) given atracurium 0.3 mg kg-1 i.v., antagonism was not attempted until the peak height of the tetanic contraction had reached approximately 50% of the control value.(ABSTRACT TRUNCATED AT 250 WORDS)
.A
Astley BA; Hughes R; Payne JP.
.I 132
.U
87049469
.S
Br J Anaesth 8703; 58(11):1296-9
.M
Adult; Atracurium/*PD; Evoked Potentials/DE; Female; Human; Male; Middle Age; Muscle Contraction/*DE; Neuromuscular Blocking Agents/*; Time Factors; Tubocurarine/*PD; Vecuronium/*PD.
.T
Reappearance of the train-of-four after neuromuscular blockade induced with tubocurarine, vecuronium or atracurium.
.P
JOURNAL ARTICLE.
.W
The characteristics of train-of-four recovery after atracurium or vecuronium were studied, under enflurane anaesthesia, and compared with those associated with tubocurarine-induced blockade. Ten patients each received vecuronium 0.1 mg kg-1, atracurium 0.5 mg kg-1 or tubocurarine 0.5 mg kg-1. Neuromuscular blockade was calculated as the percent depression of the first twitch, and was determined at the time of reappearance of the second, third and fourth twitches of the train-of-four. The pattern during recovery from blockade induced by the three neuromuscular blocking agents was similar, with T2, T3 and T4 reappearing at approximately 93%, 89% and 86% residual blockade, respectively. These results are different from those previously reported by Lee (1975) indicating that, under enflurane anaesthesia, the train-of-four count may give an incorrect estimate of the degree of neuromuscular blockade.
.A
O'Hara DA; Fragen RJ; Shanks CA.
.I 133
.U
87049470
.S
Br J Anaesth 8703; 58(11):1300-2
.M
Anesthesia, General/*MT; Anesthesia, Inhalation; Comparative Study; Enflurane; Female; Human; Male; Muscle Contraction/*DE; Neuromuscular Blocking Agents/*; Nitrous Oxide; Thiopental; Transducers; Vecuronium/*PD; Visual Perception.
.T
Comparison of visual and measured train-of-four recovery after vecuronium-induced neuromuscular blockade using two anaesthetic techniques.
.P
JOURNAL ARTICLE.
.W
This study evaluated train-of-four recovery after the administration of vecuronium, comparing measured with visually observed responses. Responses to supramaximal stimuli of the ulnar nerves were measured by a force transducer, and compared with visually observed movements of the contralateral thumb. For the 10 patients anaesthetized with nitrous oxide and enflurane, the second, third and fourth twitches visually reappeared at 84 (+/- 10)%, 76 (+/- 11)%, and 70 (+/- 12)% measured blockade, respectively. For the other 10 patients, anaesthetized with a narcotic-barbiturate technique, the second, third and fourth twitches reappeared at 81 (+/- 8)%, 68 (+/- 9)%, and 59 (+/- 11)%. These results were not different for the two anaesthetic techniques.
.A
O'Hara DA; Fragen RJ; Shanks CA.
.I 134
.U
87049471
.S
Br J Anaesth 8703; 58(11):1303-7
.M
Adult; Aged; Anesthesia, General; Cholinesterase Inhibitors/*ME; Female; Galanthamine/BL/*ME/UR; Human; Kinetics; Middle Age.
.T
Pharmacokinetics of galanthamine (a long-acting anticholinesterase drug) in anaesthetized patients.
.P
JOURNAL ARTICLE.
.W
The pharmacokinetics of the long-acting anticholinesterase drug, galanthamine, were investigated in eight patients. After i.v. injection of 0.3 mg kg-1, the decrease in the serum concentration of galanthamine followed a biexponential curve. The serum concentration decreased rapidly from 543 +/- 47 ng ml-1 to 128 +/- 14 ng ml-1 between 2 and 30 min with a T1/2 alpha of 6.42 +/- 2.15 min, and then declined more slowly with a T1/2 beta of 264 +/- 28 min. Total serum clearance of galanthamine amounted to 5.37 +/- 0.87 ml min-1 kg-1, and the renal clearance was 1.36 +/- 0.10 ml min-1 kg-1. The cumulative urinary excretion of galanthamine between 0 and 48 h after injection amounted to 28.0 +/- 5.4% of the administered dose. The biliary excretion of galanthamine during 24 h amounted to 0.2 +/- 0.1% of the dose. There was no evidence of glucuronide or sulphate conjugation of galanthamine.
.A
Westra P; van Thiel MJ; Vermeer GA; Soeterbroek AM; Scaf AH; Claessens HA.
.I 135
.U
87049472
.S
Br J Anaesth 8703; 58(11):1308-16
.M
Anesthesia, General/*; Anesthesia, Spinal/*; Animal; Cardiac Output/DE; Chlormethiazole/*ME/PD; Hemodynamics/*DE; Intestines/BS; Iodohippuric Acid/ME; Liver Circulation/DE; Regional Blood Flow/DE; Renal Circulation/DE; Sheep; Subarachnoid Space.
.T
A sheep preparation for studying interactions between blood flow and drug disposition. VI: Effects of general or subarachnoid anaesthesia on blood flow and chlormethiazole disposition.
.P
JOURNAL ARTICLE.
.W
Blood flow through and chlormethiazole extraction ratios across lungs, liver, kidneys and gut were measured in awake unrestrained sheep (controls) and with the same animals anaesthetized with 1.5% halothane or whilst undergoing high thoracic subarachnoid blockade with amethocaine. In the control-drug studies, chlormethiazole infused to sub-sedative blood concentrations produced no significant changes in haemodynamics or in the kinetics of iodohippurate (renal and hepatic blood flows). Chlormethiazole was eliminated predominantly by the liver (mean extraction ratio and clearance, respectively, 0.90 and 1.3 litre min-1) and lungs (0.15; 0.6 litre min-1). Renal clearance was absent or negligible (greater than 0.1 litre min-1). Because of pulmonary clearance, mean total body clearance was derived from analysis of pulmonary arterial concentrations. Under general anaesthesia, there were significant reductions in mean cardiac output, hepatic and renal blood flow (to 54%, 63% and 43% of control); chlormethiazole mean hepatic extraction ratios and clearance were reduced, respectively, to 82% and 56% of control, and its pulmonary and renal clearances were abolished. With subarachnoid anaesthesia there were no significant changes in haemodynamics or in chlormethiazole extraction ratios or clearances.
.A
Runciman WB; Mather LE; Ilsley AH; Carapetis RJ; Upton RN.
.I 136
.U
87049473
.S
Br J Anaesth 8703; 58(11):1317-20
.M
Adult; Aged; Bronchi/*; Bronchoscopy; Human; Intubation/AE/*MT; Male; Middle Age.
.T
Placement of double-lumen endobronchial tubes. Correlation between clinical impressions and bronchoscopic findings.
.P
JOURNAL ARTICLE.
.W
Double-lumen endobronchial tubes were placed "blindly" in 23 patients undergoing thoracotomy. Clinical criteria suggested satisfactory positioning in all cases; however, subsequent fibreoptic bronchoscopy revealed malposition in 48%. Bronchoscopic findings included the inability to view the bronchial cuff, narrowing of the bronchial lumen of the tube at the level of the cuff and herniation of the cuff over the carina. The potential hazards associated with these findings are discussed.
.A
Smith GB; Hirsch NP; Ehrenwerth J.
.I 137
.U
87049474
.S
Br J Anaesth 8703; 58(11):1321P-1340P
.M
Anesthesia/*; Anesthetics/*; Animal; Human.
.T
Proceedings of the Anaesthetic Research Society. Leeds meeting. April 11-12, 1986. Abstracts.
.P
JOURNAL ARTICLE.
.I 138
.U
87049475
.S
Br J Anaesth 8703; 58(11):1341-2
.M
Animal; Dogs; Human; Respiration, Artificial/*; Respiratory Dead Space/*; Tidal Volume.
.T
Deadspace during high frequency ventilation [letter]
.P
LETTER.
.A
Fletcher R.
.I 139
.U
87049476
.S
Br J Anaesth 8703; 58(11):1342
.M
Atracurium/*AE; Histamine Liberation/*DE; Human.
.T
Histamine liberation with atracurium [letter]
.P
LETTER.
.A
Owen RT.
.I 140
.U
87049477
.S
Br J Anaesth 8703; 58(11):1342-3
.M
Analgesia/*MT; Human; Injections, Spinal; Morphine/*AD; Thoracic Injuries/*TH.
.T
Intrathecal morphine and multiple fractured ribs [letter]
.P
LETTER.
.A
Dickson GR; Sutcliffe AJ.
.I 141
.U
87049478
.S
Br J Anaesth 8703; 58(11):1343
.M
Animal; Atracurium/*AE; Female; Human; Pre-Eclampsia/*ME; Pregnancy; Rabbits; Seizures/CI.
.T
Use of atracurium in pre-eclamptic patients [letter]
.P
LETTER.
.A
Fujita RA; Choi HJ.
.I 142
.U
87049507
.S
Br J Dermatol 8703; 115(4):421-9
.M
Adolescence; Adult; Aged; Calcitonin/BL; Cholecalciferols/*TU; Dihydroxycholecalciferols/BL/TU; Female; Human; Hydroxycholecalciferols/BL/TU; Male; Middle Age; Parathyroid Hormones/BL; Psoriasis/BL/*DT; Support, Non-U.S. Gov't.
.T
An open study of vitamin D3 treatment in psoriasis vulgaris.
.P
JOURNAL ARTICLE.
.W
Active forms of vitamin D3, 1 alpha-hydroxyvitamin D3 and 1 alpha,25-dihydroxyvitamin D3, were administered in an open-design study to 40 patients with psoriasis vulgaris in three ways: to 17 patients 1 alpha-hydroxyvitamin D3 was given orally at a dose of 1.0 micrograms/day for 6 months, to four patients 1 alpha,25-dihydroxyvitamin D3 was given orally at a dose of 0.5 microgram/day for 6 months, and 19 patients were given 1 alpha,25-dihydroxyvitamin D3 applied topically at concentration of 0.5 microgram/g of base for 8 weeks. Improvement was observed at the end of the individual study periods in 13 (76%) patients in Group 1 with a mean period of treatment (+/- SD) of 2.7 +/- 0.6 months, in one patient in Group 2 at 3 months after the start of treatment, and in 16 (84%) patients in Group 3 when the chemical was applied for 3.3 +/- 1.2 weeks. No side-effects were observed in any of these trials. These data suggest that psoriasis may respond to active metabolites of vitamin D3 and that abnormalities in vitamin D metabolism or in responsiveness of the skin cells to active metabolites of vitamin D may be involved in the pathogenesis of this skin disease.
.A
Morimoto S; Yoshikawa K; Kozuka T; Kitano Y; Imanaka S; Fukuo K; Koh E; Kumahara Y.
.I 143
.U
87049508
.S
Br J Dermatol 8703; 115(4):431-3
.M
Adolescence; Adult; Aged; Dihydroxycholecalciferols/*TU; Female; Human; Male; Middle Age; Ointments; Psoriasis/*DT.
.T
Successful treatment of psoriasis with topical application of active vitamin D3 analogue, 1 alpha,24-dihydroxycholecalciferol.
.P
JOURNAL ARTICLE.
.W
We treated 11 psoriatic patients with topical 1 alpha,24-dihydroxycholecalciferol, a new synthetic analogue of active vitamin D3. In 10 of 15 tests the lesions cleared completely within 1-4 weeks, although some relapses occurred shortly after cessation of treatment. There were no side-effects. We suggest that 1 alpha, 24(OH)2D3 merits further investigation as a potentially useful topical therapy for psoriasis.
.A
Kato T; Rokugo M; Terui T; Tagami H.
.I 144
.U
87049509
.S
Br J Dermatol 8703; 115(4):435-45
.M
Antibodies, Fungal/*AN; Antigens, Fungal/*IM; Counterimmunoelectrophoresis; Cross Reactions; Dermatomycoses/*IM; Deuteromycetes/*IM; Human; Hyphomycetes/*IM; Immunoelectrophoresis, Two-Dimensional.
.T
Circulating antibodies and antigenic cross-reactivity in Hendersonula toruloidea and Scytalidium hyalinum infections.
.P
JOURNAL ARTICLE.
.W
Twelve (34%) of thirty-five patients with an active infection on the palms or soles caused by Hendersonula toruloidea or Scytalidium hyalinum were found to have circulating antibodies to these organisms by counter immunoelectrophoresis or immunodiffusion, compared with 9% of uninfected controls. In every instance there was cross-reactivity between the positive patients' sera and the heterologous non-dermatophyte antigen. Using crossed and intermediate gel immunoelectrophoresis it was found that cytoplasmic extracts of H. toruloidea and S. hyalinum showed 34 and 41 precipitin peaks respectively, most of which were shared by both organisms. No cross-reactions were observed between the non-dermatophyte cytoplasmic extracts and hyperimmune animal antisera raised to Trichophyton rubrum, Trichophyton interdigitale, Aspergillus fumigatus or Candida albicans. Exoantigens prepared from the two non-dermatophytes showed similar cross-reactivity between the two species. It appears that H. toruloidea and S. hyalinum are very similar in antigenic structure, a finding which lends support to the view that they may be closely related. They are also antigenically distinct from other pathogenic fungi which commonly infect skin, a fact which may be useful in their cultural identification as well as their recognition in tissue specimens.
.A
Moore MK; Hay RJ.
.I 145
.U
87049511
.S
Br J Dermatol 8703; 115(4):453-66
.M
Administration, Topical; Dose-Response Relationship, Radiation; Erythema/*DT/ET; Human; Indomethacin/*AD/TU; Models, Biological; Skin/RE; Ultraviolet Rays/*AE.
.T
A quantitative study of the effect of topical indomethacin on cutaneous erythema induced by UVB and UVC radiation.
.P
JOURNAL ARTICLE.
.W
The effect of indomethacin gel on UVB and UVC erythema was assessed objectively using a reflectance instrument. When indomethacin was applied immediately after irradiation, UVR (ultraviolet radiation) dose-dependent suppression of erythema was demonstrated for both wavelengths until 36 h after irradiation when both indomethacin and control gel base-treated sites were equally erythematous. Suppression of erythema also occurred when application of indomethacin was delayed until 24 h after irradiation, showing that for both wavelengths prostaglandin synthesis remains increased throughout this period. The degree of suppression at any time, however, was no greater than that achieved by a single application immediately after irradiation, indicating that the eventual equal erythema of indomethacin and gel base-treated sites was not due to tachyphylaxis or inadequate dosage. Construction of dose-response curves for the indomethacin-responsive and indomethacin-unresponsive components of erythema shows that in human skin the difference in erythemal response to UVB and UVC radiation is not due to the formation of different mediators at these wavelengths.
.A
Farr PM; Diffey BL.
.I 146
.U
87049512
.S
Br J Dermatol 8703; 115(4):467-74
.M
Adolescence; Adult; Behavior Therapy/*; Combined Modality Therapy; Dermatitis, Atopic/DT/*TH; Human; Hydrocortisone/TU; Middle Age; Ointments; Pruritus/DT/*TH; Support, Non-U.S. Gov't.
.T
Behavioural treatment of scratching in patients with atopic dermatitis.
.P
JOURNAL ARTICLE.
.W
A behavioural method of habit reversal, in combination with a hydrocortisone cream, was compared with the use of cream alone in the treatment of 17 patients with atopic dermatitis. The patients were assigned randomly to two groups, one of which received the combination treatment and the other regular ointment treatment. The patients' skin status was assessed before and after treatment, and the patients recorded their scratching during the study. Both groups improved, but the group which received habit-reversal therapy improved significantly more. A strong correlation was found between reduction in scratching and improvement in skin status.
.A
Melin L; Frederiksen T; Noren P; Swebilius BG.
.I 147
.U
87049513
.S
Br J Dermatol 8703; 115(4):475-84
.M
Adolescence; Adrenal Cortex Function Tests; Case Report; Child; Child, Preschool; Cosyntropin/DU; Cushing's Syndrome/CI; Dermatitis, Atopic/BL/*ME; Female; Human; Hydrocortisone/BL/*ME; Infant; Male; Seborrhea/BL/*ME; Skin Absorption/*; Support, Non-U.S. Gov't.
.T
Effect of percutaneous absorption of hydrocortisone on adrenocortical responsiveness in infants with severe skin disease.
.P
JOURNAL ARTICLE.
.W
Percutaneous absorption of hydrocortisone was studied in 18 children (aged from 6 weeks to 14 1/2 years) with atopic or seborrhoeic dermatitis, by measuring their serum cortisol before and after application of 1% hydrocortisone cream. Endogenous secretion of cortisol was suppressed with dexamethasone. A 24 h absorption test was performed on nine children. In six, percutaneous absorption was detected. The highest serum cortisol level was reached within the first 6 h. A 4 h absorption test was developed on the basis of the 24 h test. This short absorption test was performed on nine children, and in eight of them absorption of hydrocortisone was detected. The rise of serum cortisol ranged from 98 to 2669 nmol/l. The 2 h ACTH test was performed to evaluate the effect of previous treatment with topical glucocorticoids. Suppressed adrenocortical function was found in five of 13 children, and was associated significantly with high post-application serum cortisol levels. This occurred more often in infants with a severe skin disorder than in older children or in those with mild or moderate skin disease.
.A
Turpeinen M; Salo OP; Leisti S.
.I 148
.U
87049514
.S
Br J Dermatol 8703; 115(4):485-93
.M
Adult; Allergens/*IM; Dermatitis, Atopic/*IM; Human; Immunologic Tests; Male; Mites/*IM; Pruritus/IM; Skin Tests.
.T
Challenge reactions in atopic dermatitis after percutaneous entry of mite antigen.
.P
JOURNAL ARTICLE.
.W
We succeeded in reproducing an eczematous lesion on the apparently normal skin of a patient with atopic dermatitis by scratching and continuous application of an ointment containing ferritin-labelled mite antigen. Percutaneous entry of mite antigen was demonstrated in skin biopsies by Fe-staining. Scratched skin first showed an urticarial reaction typical of type I allergy which later changed into an eczematous reaction typical of type IV allergy. This change was also shown histologically.
.A
Gondo A; Saeki N; Tokuda Y.
.I 149
.U
87049515
.S
Br J Dermatol 8703; 115(4):495-6
.M
Adult; Case Report; Diagnosis, Differential; Female; Human; Neutrophils; Skin Diseases/*DI; Syndrome; Syphilis/*DI.
.T
Secondary syphilis mimicking Sweet's syndrome.
.P
JOURNAL ARTICLE.
.W
We describe a patient with secondary syphilis and facial skin lesions which resembled Sweet's syndrome clinically and histologically. We suggest serological tests for syphilis in patients with Sweet's syndrome.
.A
Jordaan HF; Cilliers J.
.I 150
.U
87049516
.S
Br J Dermatol 8703; 115(4):497-9
.M
Case Report; Child; Ecthyma, Contagious/*CO; Granuloma/*ET/PA; Human; Male; Skin Diseases/*ET/PA.
.T
Giant orf in a normal individual.
.P
JOURNAL ARTICLE.
.A
Pether JV; Guerrier CJ; Jones SM; Adam AE; Kingsbury WN.
.I 151
.U
87049517
.S
Br J Dermatol 8703; 115(4):501-6
.M
Blister/*ET/PA; Burns/*CO/PA; Case Report; Cicatrix/PA; Human; Infant; Male; Microscopy, Electron.
.T
Blisters over burn scars in a child.
.P
JOURNAL ARTICLE.
.W
We present the case of an 11-month-old baby with a burn that healed normally over a month, but subsequently developed successive crops of blisters over the scar. There were no changes in his general condition. Clinical, immunological, histological and ultrastructural studies provided a diagnosis of mechanical dermatitis produced by microtrauma. Electron microscopy studies revealed the sub-epidermal nature of the blisters and the presence of underlying fibrin deposits.
.A
Pedragosa R; Serrano S; Carol-Murillo J; Hernandez JV; Vidal J.
.I 152
.U
87049519
.S
Br J Dermatol 8703; 115(4):514-5
.M
Aged; Case Report; Female; Human; Killer Cells, Natural/*IM; Lymphomatoid Granulomatosis/*IM; Skin Diseases/*IM.
.T
Natural killer cells and lymphomatoid granulomatosis [letter]
.P
LETTER.
.A
Rongioletti F; Bernengo MG; Crovato F; Rebora A.
.I 153
.U
87049520
.S
Br J Dermatol 8703; 115(4):515-6
.M
Anti-Inflammatory Agents, Non-Steroidal/*; Human; Photosensitivity Disorders/*ET; Propionates/*AE; Propionic Acids/*AE.
.T
Persistent phototoxicity after benoxaprofen [letter]
.P
LETTER.
.A
Sneddon IB.
.I 154
.U
87049559
.S
Br J Obstet Gynaecol 8703; 93(11):1121-3
.M
Female; Human; Pregnancy; Propranolol/TU; Puerperal Disorders/*DI; Thyroiditis/*DI/DT; Thyroxine/TU.
.T
Postpartum thyroiditis--an underdiagnosed disease.
.P
JOURNAL ARTICLE.
.A
Ramsay I.
.I 155
.U
87049560
.S
Br J Obstet Gynaecol 8703; 93(11):1124-31
.M
Adolescence; Adult; Colitis, Ulcerative/BL/*CO; Comparative Study; Crohn Disease/BL/*CO; Female; Hemoglobins/AN; Human; Infant, Low Birth Weight; Infant, Newborn; Labor, Induced; Labor, Premature/ET; Pregnancy; Pregnancy Complications/*ET; Retrospective Studies.
.T
The effects of inflammatory bowel disease on pregnancy: a case-controlled retrospective analysis.
.P
JOURNAL ARTICLE.
.W
Retrospective analysis of 82 pregnancies in women with either ulcerative colitis or Crohn's disease suggested that, in general, neither disease had a major effect on pregnancy outcome. The birth-weights of babies born to women with inflammatory bowel disease were marginally lower than those born to women in a control group matched for age and parity, but the difference was statistically significant only in women with Crohn's disease. In both disease groups there was a higher frequency of low haemoglobin levels in pregnancy than in the matched control groups. There were no statistically significant effects of ulcerative colitis or Crohn's disease on duration of pregnancy, mode of delivery or raised blood pressure and/or proteinuria. In the absence of a relapse, a diagnosis of inflammatory bowel disease should not influence obstetric management.
.A
Porter RJ; Stirrat GM.
.I 156
.U
87049561
.S
Br J Obstet Gynaecol 8703; 93(11):1132-5
.M
Comparative Study; Extraction, Obstetrical/*AE/*MT; Female; Human; Infant, Newborn; Infant, Newborn, Diseases/ET; Labor Complications/*TH; Labor Stage, Second; Obstetrical Forceps; Pregnancy; Puerperal Disorders/ET; Retrospective Studies; Vacuum Extraction, Obstetrical/*AE.
.T
Fetal and maternal effects of forceps and vacuum extraction.
.P
JOURNAL ARTICLE.
.A
Punnonen R; Aro P; Kuukankorpi A; Pystynen P.
.I 157
.U
87049563
.S
Br J Obstet Gynaecol 8703; 93(11):1145-9
.M
Amniotic Fluid/AN; Comparative Study; Female; Fetal Blood/AN; Fetal Membranes/AN; Human; Interferon Type I/*AN; Placenta/AN; Pregnancy/BL/*ME; Support, Non-U.S. Gov't.
.T
Alpha interferon in human pregnancy.
.P
JOURNAL ARTICLE.
.W
The concentration of interferon-alpha was measured by a specific two-site immunoradiometric assay in a variety of fluids and tissues collected during human pregnancy. Maternal blood and blood and tissues from non-pregnant adults contained little or no interferon-alpha. Fetal blood, fetal organs, placenta, membranes, amniotic fluid and decidua all contained significant and roughly equivalent amounts ranging from 1.1 to 10 u/ml (or per g of tissue). These findings demonstrate that the fetus and its immediate surroundings are permeated with interferon. It is suggested that this may play a role in regulation of the maternal-fetal graft relation.
.A
Chard T; Craig PH; Menabawey M; Lee C.
.I 158
.U
87049564
.S
Br J Obstet Gynaecol 8703; 93(11):1150-4
.M
Adult; Centrifugation/MT; Comparative Study; Female; Human; Macrophages/MI; Phagocytes/*PH; Phagocytosis/*; Pregnancy/BL/*PH; Staphylococcus epidermidis.
.T
Enhanced phagocytosis of mononuclear phagocytes in pregnancy.
.P
JOURNAL ARTICLE.
.W
The phagocytic activity of peripheral blood mononuclear phagocytes for Staphylococcus epidermis of healthy non-pregnant and pregnant women throughout pregnancy was examined in relation to gestational age. The study included 30 healthy non-pregnant women and 90 healthy pregnant women equally distributed across the three trimesters. Two variables were investigated: the number of mononuclear cells in phagocytosis and the average number of bacteria per monocyte in phagocytosis. As pregnancy progressed a gradual and significant increase was found in the number of monocytes in phagocytosis and a significantly higher proportion of macrophages with six or more bacteria per phagocyte.
.A
Koumandakis E; Koumandaki I; Kaklamani E; Sparos L; Aravantinos D; Trichopoulos D.
.I 159
.U
87049566
.S
Br J Obstet Gynaecol 8703; 93(11):1161-2
.M
Adult; Female; Heparin/TU; Human; Pregnancy; Pregnancy Complications, Cardiovascular/*DI/DT; Pulmonary Embolism/*DI/DT; Warfarin/TU.
.T
An unusual presentation of pulmonary thromboembolism in late pregnancy. Case report.
.P
JOURNAL ARTICLE.
.A
Hussein IY; Critchley HO.
.I 160
.U
87049568
.S
Br J Obstet Gynaecol 8703; 93(11):1166-8
.M
Case Report; Endometrial Hyperplasia/*CO/PA; Female; Hemangioma/*CO/PA; Human; Middle Age; Ovarian Neoplasms/*CO/PA.
.T
Haemangioma of the ovary with associated endometrial hyperplasia. Case report.
.P
JOURNAL ARTICLE.
.A
Grant JW; Millward-Sadler GH.
.I 161
.U
87049569
.S
Br J Obstet Gynaecol 8703; 93(11):1169-70
.M
Adult; Carcinoma, Squamous Cell/PA/*SC; Case Report; Cervix Neoplasms/*PA; Female; Human; Ovarian Neoplasms/PA/*SC.
.T
Ovarian metastasis from stage 1B squamous carcinoma of the cervix. Case report.
.P
JOURNAL ARTICLE.
.A
Cassidy LJ; Kennedy JH.
.I 162
.U
87049570
.S
Br J Obstet Gynaecol 8703; 93(11):1171-5
.M
Aged; Female; Human; Menopause; Ovarian Neoplasms/BL/*PA; Sertoli Cell Tumor/BL/*PA; Steroids/BL.
.T
A feminizing Sertoli-Leydig cell tumour in a postmenopausal woman. Case report.
.P
JOURNAL ARTICLE.
.A
Dhont M; Vandekerckhove F; Praet M; Vanluchene E; Vandekerckhove D.
.I 163
.U
87049571
.S
Br J Obstet Gynaecol 8703; 93(11):1176-80
.M
Adult; Arteritis/*PA; Case Report; Cervix Diseases/*PA; Female; Human; Middle Age; Necrosis.
.T
Isolated arteritis of the uterine cervix. Three case reports.
.P
JOURNAL ARTICLE.
.A
Padwell A.
.I 164
.U
87049572
.S
Br J Obstet Gynaecol 8703; 93(11):1181-6
.M
Adult; Case Report; Female; Human; Hydatidiform Mole/*GE/PA; Karyotyping; Mosaicism; Pregnancy; Uterine Neoplasms/*GE/PA.
.T
Diploid complete hydatidiform mole, mosaic for normally fertilized cells and androgenetic homozygous cells. Case report.
.P
JOURNAL ARTICLE.
.A
Ford JH; Brown JK; Lew WY; Peters GB.
.I 165
.U
87049573
.S
Br J Obstet Gynaecol 8703; 93(11):1187-90
.M
Carcinoma, Mucinous/PA/*SC; Case Report; Cervix Neoplasms/PA/*SC; Female; Gallbladder Neoplasms/*PA; Human; Middle Age.
.T
Carcinoma of the gall bladder metastatic to the cervix. Case report.
.P
JOURNAL ARTICLE.
.A
Hall PA; Lemoine NR; Ryan JF.
.I 166
.U
87049575
.S
Br J Ophthalmol 8703; 70(10):718-23
.M
Convergence, Ocular/*; Electrooculography; Eye Movements/*; Form Perception/*PH; Human; Pattern Recognition, Visual/*PH; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S..
.T
Vergence amplitudes with random-dot stereograms.
.P
JOURNAL ARTICLE.
.W
Random-dot stereograms were found to be capable of producing fusional vergence amplitudes in the absence of monocular contours. These vergence amplitudes are not an artefact of monocular contours provided by the target borders or test instrument and are comparable in range to vergence amplitudes measured clinically with second degree fusion targets in an amblyoscope. We conclude that diplopia of monocularly recognisable contours is not necessary for producing fusional vergence amplitudes.
.A
Archer SM; Miller KK; Helveston EM; Ellis FD.
.I 167
.U
87049576
.S
Br J Ophthalmol 8703; 70(10):724-6
.M
Cataract Extraction/MT; Human; Lens Capsule, Crystalline/SU; Lenses, Intraocular/*; Surgical Instruments/*.
.T
Posterior chamber intraocular lens implantation--a new forceps to simplify capsular bag fixation.
.P
JOURNAL ARTICLE.
.W
The case for capsular bag fixation of the Sinsky-Kratz type of posterior chamber intraocular implant lens is presented, and the various methods in use to position implant lenses are outlined. The new forceps are described and the rationale for their adoption and use is given in an illustrated, step-by-step fashion. Their additional use in anterior chamber intraocular lens implantation is mentioned. There is a brief summary of the author's experience with this instrument.
.A
Bates R.
.I 168
.U
87049579
.S
Br J Ophthalmol 8703; 70(10):737-41
.M
Aged; Cataract Extraction/*; Cornea/PA; Corneal Diseases/*ET/PA; Female; Human; Male; Middle Age; Ultraviolet Rays/*AE; Visual Acuity.
.T
Regression of Labrador keratopathy following cataract extraction.
.P
JOURNAL ARTICLE.
.W
Labrador keratopathy (LK) is an acquired corneal degeneration thought to be caused by chronic exposure to solar irradiation. Reports so far suggest that it is a progressive or at least a stationary condition. There are no detailed reports on recommended therapy. A prospective clinical study was conducted to show regression of LK following extracapsular cataract extraction. Seventeen black patients (26 eyes) with LK and mature cataracts underwent extracapsular cataract extraction. The severity of the LK was recorded photographically pre- and postoperatively. The follow-up ranged from 6 to fifteen months. Twenty-four eyes (92%) showed regression of the LK. The reduction in exposure to ultraviolet light as a result of aphakic photophobia could be one of the factors which have led to the regression of the LK.
.A
Dahan E; Judelson J; Welsh NH.
.I 169
.U
87049581
.S
Br J Ophthalmol 8703; 70(10):748-50
.M
Adolescence; Adult; Athletic Injuries/*EP; England; Eye Injuries/*EP; Eye Protective Devices; Female; Human; Male; Soccer; Tennis.
.T
Sussex Eye Hospital sports injuries.
.P
JOURNAL ARTICLE.
.W
To assess the prevalence of sports eye injuries in our area a register was kept over the 18 months from October 1982 to March 1984. Squash, association football, badminton, and tennis were the main offenders. The severest injury was from a golf ball, involving a fractured zygoma. There was one retinal dialysis, and one lens dislocation requiring extraction. Spectacles were broken in six cases and a contact lens in one. Glass fragments needed operative removal in one case, but there were no penetrating injuries. The value of eye protection, not worn by any of our patients, is emphasised.
.A
Gregory PT.
.I 170
.U
87049584
.S
Br J Ophthalmol 8703; 70(10):764-5
.M
Capillaries/PA; Case Report; Choroid Neoplasms/*BS/PA; Fluorescein Angiography; Human; Male; Melanoma/*BS/PA; Middle Age; Neovascularization/PA; Retinal Vessels/*PA; Support, Non-U.S. Gov't.
.T
Inferences from beading of a retinal vein draining a choroidal melanoma.
.P
JOURNAL ARTICLE.
.W
Beading of a retinal vein draining a choroidal melanoma is reported, showing that the endothelial proliferation producing the beading is a response to some blood borne factor(s) traversing the vein and that retinal capillary non-perfusion adjacent to the beaded vein is not a necessary part of the process.
.A
Johnson RN; Irvine AR; Char DH.
.I 171
.U
87049585
.S
Br J Ophthalmol 8703; 70(10):766-8
.M
Fundus Oculi; Human; Lighting; Photography/*; Retina/*PA; Retinal Vessels/PA.
.T
Photographic recording of slit-lamp appearances of the ocular fundus.
.P
JOURNAL ARTICLE.
.W
The four methods of illumination in the use of slit-lamp biomicroscopy of the anterior segment, described first by Vogt, are equally useful in the posterior part of the eye. Examination of the ocular fundus is more difficult. In particular, photography of the central and peripheral parts of the fundus demands additional technical arrangements if all the appearances of biomicroscopy are to be recorded.
.A
Kenyeres P; Slezak H.
.I 172
.U
87049586
.S
Br J Ophthalmol 8703; 70(10):769-71
.M
Dose-Response Relationship, Radiation; Eyeglasses/*; Human; Lens, Crystalline/RE; Pupil; Retina/RE; Sunlight/*AE; Ultraviolet Rays/AE.
.T
Sunglasses--an ocular hazard?
.P
JOURNAL ARTICLE.
.W
A suggestion that protective eye gear can pose a threat either to the crystalline lens or to the retina is examined from an epidemiological point of view. It is concluded that it may accentuate a pre-existing high-risk hazard but has little significance for low-risk hazards.
.A
Weale RA.
.I 173
.U
87049587
.S
Br J Ophthalmol 8703; 70(10):772-8
.M
Adult; Aneurysm/*PA; Blood Coagulation Tests; Case Report; Diabetic Retinopathy/BL/*PA; Female; Fluorescein Angiography; Hemoglobin A, Glycosylated/AN; Human; Male; Middle Age; Retinal Vessels/*PA.
.T
Retinal cotton-wool spots: an early finding in diabetic retinopathy?
.P
JOURNAL ARTICLE.
.W
Five insulin dependent diabetic patients are reported on who had a few small retinal cotton-wool spots or 'soft exudates' either totally isolated or associated with fewer than 10 microaneurysms. These observations suggest that cotton-wool spots may be an early finding in diabetic retinopathy. Significant biological abnormalities in these patients were high levels of glycosylated haemoglobin and mild increases in thrombin generation, indicating slight activation of the coagulation system. The possible significance of these clinical and biological findings is discussed.
.A
Roy MS; Rick ME; Higgins KE; McCulloch JC.
.I 174
.U
87049588
.S
Br J Ophthalmol 8703; 70(10):779-81
.M
Adult; Case Report; Human; Male; Optic Atrophy/*ET; Plant Poisoning/*; Vision Disorders/ET.
.T
The presumed neurotoxic effects of Catha edulis--an exotic plant now available in the United Kingdom.
.P
JOURNAL ARTICLE.
.W
Bilateral optic atrophy is reported in two patients who, although they were long-standing users of the leaves of Catha edulis, had chewed larger quantities than usual. Since the leaves of this plant are used widely throughout its native area as the source of a mildly stimulant narcotic, the effect in these cases may be an idiosyncratic reaction to an unusually large dose.
.A
Roper JP.
.I 175
.U
87049589
.S
Br J Ophthalmol 8703; 70(10):782-96
.M
Case Report; Child; Child, Preschool; Female; Human; Laurence-Moon-Biedl Syndrome/*PA; Male; Microscopy, Electron; Mitochondria/*UL; Pedigree; Pigment Epithelium of Eye/UL; Retina/*UL; Retinal Degeneration/GE/*PA; Rods and Cones/UL; Support, Non-U.S. Gov't.
.T
Histopathology of mitochondrial cytopathy and the Laurence-Moon-Biedl syndrome.
.P
JOURNAL ARTICLE.
.W
Clinical and histopathological studies of two patients with distinctly different inherited juvenile retinal dystrophies indicate that the ocular defect in mitochondrial cytopathy involves the underlying pigment epithelium, whereas in the Laurence-Moon-Biedl syndrome the photoreceptor cells are primarily affected.
.A
Runge P; Calver D; Marshall J; Taylor D.
.I 176
.U
87050029
.S
Blood 8703; 68(6):1196-200
.M
Antibodies, Monoclonal/*IM; Antibody-Dependent Cell Cytotoxicity; Bone Marrow/*IM/PH; Endothelium/*IM; Fibroblasts/*IM; Hematopoiesis; Human; Stem Cells/IM; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S..
.T
Lysis of human fibroblast colony-forming cells and endothelial cells by monoclonal antibody (6-19) and complement.
.P
JOURNAL ARTICLE.
.W
The murine IgG2a monoclonal antibody 6-19 binds to a wide variety of nonhematopoietic cells including human marrow-derived stromal cells but does not bind to marrow or peripheral blood cells. We studied the effects of this antibody and rabbit complement on marrow cells. Fibroblast colonies were eliminated from light density marrow cells by a single incubation with monoclonal antibody 6-19 and complement. The growth and composition of granulocytic and erythroid colonies were unaffected. Specific complement mediated cytotoxicity of the antibody was confirmed on passaged human fibroblasts derived from marrow (more than 99.6% of fibroblasts are killed by a single treatment). Similar results were obtained with human umbilical cord endothelial cells. In addition, such treatment abolished the initiation of Dexter culture stroma. Incubation of bone marrow cell suspensions with this antibody and complement will allow the study of stroma-free marrow cells in long-term liquid cultures.
.A
Abboud CN; Duerst RE; Frantz CN; Ryan DH; Liesveld JL; Brennan JK.
.I 177
.U
87050030
.S
Blood 8703; 68(6):1201-6
.M
Anemia, Macrocytic/*PA/PP; Animal; Bone Marrow/CY/*PH; Cell Differentiation; Cell Division; Colony-Forming Units Assay; Growth Inhibitors/RE; Growth Substances/PD; Hematopoiesis/*; Mice; Mice, Mutant Strains/*PH; Radiation, Ionizing.
.T
Sl/Sld mouse bone marrow stroma in vitro contains an active radiation-sensitive inhibitor of normal hemopoiesis.
.P
JOURNAL ARTICLE.
.W
Sl/Sld mice have a defective hemopoietic microenvironment. It has been assumed, based upon previous studies, that the primary abnormality in these mice is simply lack of a necessary supportive or inductive material within the hemopoietic stroma. We used in vitro long-term bone marrow cultures to characterize further the nature of the hemopoietic microenvironmental defect in Sl/Sld mice. Sl/Sld mouse bone marrow cells consistently produced less than 10% of the total hemopoietic cells and multipotent and unipotent hemopoietic progenitor cells produced in cultures of marrow from normal, congenic +/+ mice. If fresh Sl/Sld and +/+ marrow cells were mixed prior to establishing long-term marrow cultures, there was a direct correlation between number of Sl/Sld cells added and degree of inhibition of +/+ hemopoiesis. A pre-established, confluent Sl/Sld adherent stromal layer inhibited hemopoiesis by fresh +/+ marrow cells by nearly 70%, as compared with dishes with irradiated +/+ or no stroma. This inhibitory effect was abrogated by irradiation of the Sl/Sld stroma prior to addition of the fresh +/+ marrow cells. Similarly, unirradiated, but not 9 to 200 Gy irradiated Sl/Sld stroma inhibited proliferation of the factor-dependent FDC-P1 hemopoietic progenitor cell line. Thus, the Sl/Sld hemopoietic microenvironment actively inhibits hemopoiesis in vitro, and this inhibition can be at least partially eliminated by irradiation of the Sl/Sld stroma.
.A
Zuckerman KS; Prince CW; Ribadeneira M.
.I 178
.U
87050034
.S
Blood 8703; 68(6):1224-31
.M
Antibodies, Monoclonal/DU; Blood Platelets/DE/*ME; Calcium/PH; Epinephrine/*PD; Fibrinogen/ME; Human; Magnesium/ME; Platelet Aggregation/*/DE; Platelet Membrane Glycoproteins/DE/*ME; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Time Factors.
.T
Expression of fibrinogen receptors during activation and subsequent desensitization of human platelets by epinephrine.
.P
JOURNAL ARTICLE.
.W
Epinephrine causes platelet aggregation and secretion by interacting with alpha 2-adrenergic receptors on the platelet surface. Platelet aggregation requires the binding of fibrinogen to a specific receptor on the membrane glycoprotein IIb-IIIa complex. Although the IIb-IIIa complex is identifiable on the surface of resting platelets, the fibrinogen receptor is expressed only after platelet activation. The current studies were designed to examine the effect of occupancy of platelet alpha 2-adrenergic receptors by epinephrine on the expression of fibrinogen receptors and on the aggregation of platelets. The ability of epinephrine to induce the expression of fibrinogen receptors was studied under two different conditions: acute stimulation (less than 1 min) and prolonged stimulation (50 to 90 min), the latter of which is associated with a reduction or "desensitization" of the platelet aggregation response. Expression of the fibrinogen receptor was monitored with 125I-fibrinogen as well as with 125I-PAC-1 (PAC-1), a monoclonal antibody that binds to the glycoprotein IIb-IIIa complex only after platelets are activated. Epinephrine caused an immediate increase in PAC-1 and fibrinogen binding that was dependent on occupancy of the alpha 2-receptor by epinephrine and on the presence of extracellular free Ca (KCa = 30 mumol/L). By itself, 1 mmol/L Mg was unable to support induction of the fibrinogen receptor by epinephrine. However, it did decrease the Ca requirement by about two orders of magnitude. Prolonged stimulation of unstirred platelets by epinephrine led to a 70% decrease in the aggregation response when the platelets were subsequently stirred. Despite their decreased aggregation response, desensitized platelets bound PAC-1 and fibrinogen normally, indicating that the loss of aggregation was not due simply to a decrease in fibrinogen receptor expression. Although desensitization was not affected by pretreatment of the platelets with aspirin, it was partially prevented when extracellular Ca was chelated by EDTA during the long incubation with epinephrine. These studies demonstrate that once platelet alpha 2-adrenergic receptors are occupied by epinephrine, extracellular Ca is involved in initiating the aggregation response by supporting the induction of the fibrinogen receptor and the binding of fibrinogen. Furthermore. Ca-dependent reactions subsequent to fibrinogen binding may be necessary for maximal platelet aggregation and are impaired when platelets become desensitized to epinephrine.
.A
Shattil SJ; Motulsky HJ; Insel PA; Flaherty L; Brass LF.
.I 179
.U
87050049
.S
Blood 8703; 68(6):1329-32
.M
Cell Membrane/UL; Fetal Blood/PA; Human; Infant, Newborn; Lymphocytes/*PA; Microscopy, Electron, Scanning; Microvilli/UL; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Wiskott-Aldrich Syndrome/DI/*PA.
.T
Morphological abnormalities in the lymphocytes of patients with the Wiskott-Aldrich syndrome.
.P
JOURNAL ARTICLE.
.W
Lymphocytes from 18 patients with the Wiskott-Aldrich Syndrome (WAS) were examined by scanning electron microscopy (SEM). Most peripheral blood lymphocytes from normal individuals are covered with slender microvillus projections, but a large proportion of lymphocytes from WAS patients were found to be relatively devoid of microvilli. A lymphocyte morphology scoring system was developed to quantify the density of microvilli: Grade 4 classified those lymphocytes with greater than 75% of the surface covered with microvilli with progressive decrements to grade 1, which were those without microvilli. The mean lymphocyte morphology score of eight normal individuals was 3.62 +/- .22. The mean lymphocyte score of WAS patients was substantially lower (2.89 +/- .27, P less than .001). In addition, WAS lymphocytes often were qualitatively abnormal, with short, blunted microvilli. These morphological criteria were used to diagnose WAS from the cord blood lymphocytes of one "at-risk" patient. Thus, WAS is the first primary immunodeficiency in which morphological abnormalities have been identified that can aid in diagnosis.
.A
Kenney D; Cairns L; Remold-O'Donnell E; Peterson J; Rosen FS; Parkman R.
.I 180
.U
87050056
.S
Blood 8703; 68(6):1376-83
.M
Erythrocyte Deformability/*; Erythrocyte Membrane/*PH/UL; Erythrocytes/DE; Heinz Bodies/*/UL; Human; Membrane Proteins/BL; Microscopy, Electron; Molecular Weight; Oxidation-Reduction; Phenylhydrazines/PD; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S..
.T
Quantitative relationship between Heinz body formation and red blood cell deformability.
.P
JOURNAL ARTICLE.
.W
The ultimate cause of destruction of red blood cells (RBCs) after oxidative damage with Heinz body formation is not well understood. We correlated the changes in RBC morphology and membrane protein composition after oxidant treatment with the alterations in deformability of whole cells and cell membranes. The incubation of RBCs with phenylhydrazine concentrations of 0.3 to 100 mg/dL at 37 degrees C for one hour led to a dose-dependent formation of Heinz bodies, ranging from isolated Heinz bodies at 1 mg/dL to a confluent coating of the inner membrane surface at 100 mg/dL phenylhydrazine. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis revealed the presence of a large quantity of hemoglobin bound to the ghost membrane of treated RBCs. Electrophoresis with and without dithiothreitol indicated that disulfide bridges are abundant between hemoglobin molecules and are also present among membrane proteins but are not the major bond between hemoglobin and membrane. Changes of spectrin, ankyrin, band 3, and band 6 and the appearance of a 260,000-dalton complex were also observed. With phenylhydrazine concentrations below 30 mg/dL, even in the presence of multiple Heinz bodies, the RBC deformability measured by filtration through 2.6-, 4.5-, and 6.8-microns pores and the membrane deformability determined by a filter aspiration technique were not altered. With 100 mg/dL phenylhydrazine, when the entire membrane was coated with Heinz bodies, RBC filterability and membrane deformability were drastically reduced. These results indicate that oxidative damage of RBCs with discrete Heinz body formation causes focal membrane rigidification but does not affect the global cellular deformability until the Heinz bodies nearly cover the entire cell endoface.
.A
Reinhart WH; Sung LP; Chien S.
.I 181
.U
87050059
.S
Blood 8703; 68(6):1394-7
.M
Consanguinity; Fetal Hemoglobin/GE; Gene Amplification; Globin/*GE; Haplotypes; Homozygote; Human; Pedigree; Support, Non-U.S. Gov't; Support, U.S. Gov't, P.H.S.; Thalassemia/*GE.
.T
Beta zero-thalassemia in association with a gamma-globin gene quadruplication.
.P
JOURNAL ARTICLE.
.W
We have studied the hematology, hemoglobin composition, and globin gene arrangements in one young Turkish boy with a beta zero-thalassemia homozygosity and in 11 of his relatives. Evidence is presented that the chromosome with the beta zero-thalassemia determinant carries a gamma-globin gene quadruplication, perhaps in a -G gamma-G gamma-G gamma-A gamma-gene arrangement. The eight gamma-globin genes in this patient produced G gamma and A gamma chains in a 95 to 5 ratio, and nearly 99% of the patient's hemoglobin was of the fetal type. The clinical condition resembled that of a thalassemia intermedia. HbF levels in eight beta-thalassemia heterozygotes varied between 0.5 and 4.2% and the percentages of G gamma in this HbF averaged at 87% or 95%; this level is to some extent related to the haplotype of the normal chromosome. All subjects carried four alpha-globin genes; a new BglII polymorphism was observed within the psi alpha-globin gene.
.A
Yang KG; Liu JZ; Kutlar F; Kutlar A; Altay C; Gurgey A; Huisman TH.
.I 182
.U
87050061
.S
Blood 8703; 68(6):1402-6
.M
Cell Differentiation/DE; Cell Division/DE; Cell Line; Dimethyl Sulfoxide/PD; Drug Resistance; Granulocytes/*CY; Human; Neuraminidase/ME; Sialic Acids/*PH; Sialoglycoproteins/*PH; Support, U.S. Gov't, P.H.S.; Thioguanine/PD; Tretinoin/PD.
.T
Hyposialylation of differentiation-inducer-resistant HL-60 cells.
.P
JOURNAL ARTICLE.
.W
The total sialic acid concent of retinoic acid (RA)-resistant or 6-thioguanine (6TG)-resistant HL-60 cells was more than tenfold lower and of dimethylsulfoxide (DMSO)-resistant HL-60 cells was approximately twofold lower than that of parental, wild-type (wt) HL-60 cells. Neuraminidase-inaccessible, ie residual cell-associated sialic acid after neuraminidase treatment, was four- to twelvefold lower in the three differentiation-inducer-resistant sublines than in the parent line. Neuraminidase treatment of 125I-labeled surface membrane glycoproteins (SMGs) from wt HL-60 cells converted the two-dimensional gel electrophoretic pattern to one having features in common with RA- and 6TG-resistant cells. However, neuraminidase treatment did not alter the sensitivity of wt HL-60 cells to differentiation induction by RA, hypoxanthine (purine base), or DMSO. These results indicate that differences in peripheral, neuraminidase-accessible sialic acids are important determinants of the gel electrophoretic mobility of the SMGs of the HL-60 line and sublines but are not likely related to the differentiation-resistance mechanism. Further studies are required to determine if hyposialylation of cryptic, neuraminidase-inaccessible sites has functional significance.
.A
Gallagher RE; Giangiulio DA; Chang CS; Glover CJ; Felsted RL.
.I 183
.U
87050062
.S
Blood 8703; 68(6):1407-10
.M
Animal; Blood Proteins/*TO; Cytotoxicity, Immunologic; Drug Synergism; Human; Hydrogen Peroxide/TO; Kinetics; Mice; Neoplasms, Experimental/*IM; Neutrophils/*PH; Rabbits; Species Specificity; Support, U.S. Gov't, Non-P.H.S.; Support, U.S. Gov't, P.H.S..
.T
In vitro tumor cell cytolysis mediated by peptide defensins of human and rabbit granulocytes.
.P
JOURNAL ARTICLE.
.W
We examined the activity of defensins, cysteine-rich cationic peptides that are abundant in the cytoplasmic granules of human and rabbit granulocytes, against various tumor targets. The three human defensins, HNP-1, HNP-2, and HNP-3, lysed human and murine targets in chromium release and dye exclusion assays. Defensin-mediated tumor cell lysis was concentration-dependent, inhibited by serum, and dependent on temperature-sensitive events. Lysis was first detected by three hours of incubation and it reached a plateau between eight and 14 hours. In vitro exposure of murine teratocarcinoma cells to HNP 1-3 abrogated their oncogenicity in vivo. Nonmalignant target cells were also susceptible to defensin-mediated lysis. Four rabbit granulocyte defensins exerted marked (NP-1, NP-2) or moderate (NP-3a, NP-3b) cytotoxic activity, whereas defensin NP-5 was not cytotoxic. When tumor cells were incubated with human defensins in combination with hydrogen peroxide, synergistic cytotoxicity was detected. As defensins are released from granulocytes by various stimuli, their release could contribute to extracellular cytotoxicity which is independent of reactive oxygen intermediates.
.A
Lichtenstein A; Ganz T; Selsted ME; Lehrer RI.
.I 184
.U
87050064
.S
Blood 8703; 68(6):1415
.M
Glycoproteins/*DF; Human; Thrombosis/*GE.
.T
Mode of inheritance of type II protein S deficiency [letter]
.P
LETTER.
.A
Vicente V; Alberca I; Castro M; Lopez Borrasca A.
.I 185
.U
87050065
.S
Blood 8703; 68(6):1415-6
.M
Anemia, Sickle Cell/*BL; Erythrocytes, Abnormal/PH; Hemoglobin, Sickle/*; Hemoglobins; Human; Polymers.
.T
Deoxyhemoglobin S polymer formation in sickle cells [letter]
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LETTER.
.A
Schechter AN; Noguchi CT; Rodgers GP.
.I 186
.U
87050482
.S
Br J Rheumatol 8703; 25(4):328-30
.M
Arthritis, Rheumatoid/*EP/ET; Great Britain; Human; Time Factors; United States.
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Recent trends in rheumatoid arthritis.
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JOURNAL ARTICLE.
.A
Silman AJ.
.I 187
.U
87050485
.S
Br J Rheumatol 8703; 25(4):342-4
.M
Aged; Anti-Inflammatory Agents/*AE/TU; Arthritis, Rheumatoid/*CO/DT; Female; Human; Male; Middle Age; Osteoarthritis/CO/DT; Peptic Ulcer/CI/*ET.
.T
Peptic ulcer in rheumatoid arthritis--intrinsic or related to drug therapy?
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JOURNAL ARTICLE.
.W
The reported incidence of peptic ulcer disease (PUD) in patients with rheumatoid arthritis (RA) is higher than that of the general population. Unusual susceptibility to PUD in RA, independent of therapy, has been suggested. To compare RA patients with others who had similar drug exposure but no known predisposition to PUD, 120 patients hospitalized for treatment of severe arthritis (65 with RA, 55 with osteoarthritis) were assessed by questionnaire for PUD history, drug history and other relevant variables. The relationship of PUD to sex distribution, smoking, alcohol consumption and anti-inflammatory therapy followed expected patterns. We found high but similar PUD rates in RA and osteoarthritis (OA) patients (RA 15%, OA 18%). This suggests that a common factor (probably drugs) is responsible. We feel that the documented high incidence of PUD in RA is most probably related to drug therapy. Available methods cannot determine if PUD ever occurs as a primary manifestation of RA.
.A
Malone DE; McCormick PA; Daly L; Jones B; Long A; Bresnihan B; Molony J; O'Donoghue DP.
.I 188
.U
87050490
.S
Br J Rheumatol 8703; 25(4):366-71
.M
Adrenal Cortex Hormones/*TU; Adult; Aged; Arthritis, Rheumatoid/BL/*DT; Female; Human; In Vitro; Leukocyte Count/DE; Male; Middle Age; Monocytes/DE/*ME; Prednisolone/PD; Superoxide/*BL.
.T
Effect of corticosteroid therapy on blood monocyte superoxide generation in rheumatoid arthritis: studies in vitro and ex vivo.
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JOURNAL ARTICLE.
.W
Rates of superoxide (SA) generation by blood monocytes stimulated ex vivo were studied before and during corticosteroid treatment of rheumatoid arthritis (RA) patients, in control patients and in healthy controls. The direct effect on stimulated SA production of pre-incubating cells with prednisolone in vitro was also studied. Significant inhibition of monocyte SA output stimulated with IgG-treated zymosan (ITZ) and fluoride ion (F), but not serum-treated zymosan (STZ) was demonstrated following steroid therapy in RA. No inhibitory effect of prednisolone could be demonstrated in vitro, using ITZ, STZ and F as stimuli. Our data on blood monocyte yields, size and cytochemistry suggest that the in vivo effect is due to a shift in blood monocyte traffic.
.A
Bell AL; Hurst NP; Nuki G.
.I 189
.U
87050491
.S
Br J Rheumatol 8703; 25(4):372-5
.M
Actuarial Analysis; Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid/*DT; Azathioprine/AD/AE/*TU; Comparative Study; Female; Human; Male; Methotrexate/AD/AE/*TU; Middle Age; Support, Non-U.S. Gov't; 6-Mercaptopurine/AD/AE/*TU.
.T
Comparison of methotrexate with azathioprine or 6-mercaptopurine in refractory rheumatoid arthritis: a life-table analysis.
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JOURNAL ARTICLE.
.W
Methotrexate (MTX) appears to be useful in patients with rheumatoid arthritis (RA) refractory to other drugs but its long-term toxicity and efficacy are uncertain. A retrospective study of MTX in such patients in comparison with the purine analogues, azathioprine and 6-mercaptopurine was made using life-table analysis. Eighty-four patients took MTX in a median dose of 7.5 mg/week whilst 55 received purine analogues, 100 mg/day (median). By 12 months, 19.3% of patients had ceased MTX due to toxicity, compared with 29.3% for purine analogues. Toxicity severe enough to warrant stopping therapy was uncommon after 8 months with either drug. At 12 months 61.5% of the MTX patients had achieved defined criteria of improvement compared with 25.6% for the purine analogues (p less than 0.05). The number of patients improving on purine analogues did not increase substantially after 6 months, whereas the number improving with MTX continued to 12 months. MTX in a low-dose regimen is useful in refractory RA and superior to low-dose purine analogues.
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Sambrook PN; Champion GD; Browne CD; Cohen ML; Compton P; Day RO; de Jager J.
.I 190
.U
87050492
.S
Br J Rheumatol 8703; 25(4):376-9
.M
Azathioprine/AE/TU; Chlorambucil/AE/TU; Connective Tissue Diseases/*DT/GE; Cyclophosphamide/AE/TU; Drug Resistance; Human; Hypoxanthine Phosphoribosyltransferase/*GE; Immunosuppressive Agents/*AE/TU; Lymphocytes/*DE/EN; Mutation/*.
.T
Thioguanine-resistant mutations induced by cytotoxic drugs in lymphocytes of patients with connective tissue diseases.
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JOURNAL ARTICLE.
.W
Cells with mutations at